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Molecules 2013, 18(8), 9727-9734; doi:10.3390/molecules18089727
Article

Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

1,2,†, 1,5,†, 3, 1,* , 2,* , 1,2 and 4
Received: 29 May 2013; in revised form: 26 July 2013 / Accepted: 29 July 2013 / Published: 14 August 2013
(This article belongs to the Section Metabolites)
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Abstract: Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
Keywords: Uncaria sessilifructus; uncarilic acid; secouncarilic acid; triterpenoids Uncaria sessilifructus; uncarilic acid; secouncarilic acid; triterpenoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, M.-J.; Liu, B.; Liao, S.-G.; Xu, Y.-K.; Feng, D.-Q.; Ji, K.-L.; Li, Y. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus. Molecules 2013, 18, 9727-9734.

AMA Style

Zhang M-J, Liu B, Liao S-G, Xu Y-K, Feng D-Q, Ji K-L, Li Y. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus. Molecules. 2013; 18(8):9727-9734.

Chicago/Turabian Style

Zhang, Mao-Juan; Liu, Bing; Liao, Shang-Gao; Xu, You-Kai; Feng, De-Qiang; Ji, Kai-Long; Li, Yan. 2013. "Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus." Molecules 18, no. 8: 9727-9734.


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