Molecules 2013, 18(8), 9727-9734; doi:10.3390/molecules18089727
Article

Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

1,2,†, 1,5,†, 3, 1,* email, 2,* email, 1,2 and 4
1 Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China 2 College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Chenggong, Kunming 650200, Yunnan, China 3 Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang 550004, Guizhou, China 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China 5 Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 29 May 2013; in revised form: 26 July 2013 / Accepted: 29 July 2013 / Published: 14 August 2013
(This article belongs to the Section Natural Products)
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Abstract: Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
Keywords: Uncaria sessilifructus; uncarilic acid; secouncarilic acid; triterpenoids

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MDPI and ACS Style

Zhang, M.-J.; Liu, B.; Liao, S.-G.; Xu, Y.-K.; Feng, D.-Q.; Ji, K.-L.; Li, Y. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus. Molecules 2013, 18, 9727-9734.

AMA Style

Zhang M-J, Liu B, Liao S-G, Xu Y-K, Feng D-Q, Ji K-L, Li Y. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus. Molecules. 2013; 18(8):9727-9734.

Chicago/Turabian Style

Zhang, Mao-Juan; Liu, Bing; Liao, Shang-Gao; Xu, You-Kai; Feng, De-Qiang; Ji, Kai-Long; Li, Yan. 2013. "Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus." Molecules 18, no. 8: 9727-9734.

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