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Molecules 2013, 18(8), 9727-9734; doi:10.3390/molecules18089727

Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

1,2,†, 1,5,†, 3, 1,* , 2,* , 1,2 and 4
1 Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China 2 College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Chenggong, Kunming 650200, Yunnan, China 3 Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang 550004, Guizhou, China 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China 5 Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 29 May 2013 / Revised: 26 July 2013 / Accepted: 29 July 2013 / Published: 14 August 2013
(This article belongs to the Section Natural Products)
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Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
Keywords: Uncaria sessilifructus; uncarilic acid; secouncarilic acid; triterpenoids Uncaria sessilifructus; uncarilic acid; secouncarilic acid; triterpenoids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, M.-J.; Liu, B.; Liao, S.-G.; Xu, Y.-K.; Feng, D.-Q.; Ji, K.-L.; Li, Y. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus. Molecules 2013, 18, 9727-9734.

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