Molecules 2013, 18(8), 9179-9194; doi:10.3390/molecules18089179
Article

Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats

1 Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Health Science Center, Federal University of Santa Maria (UFSM), Santa Maria, RS 97105-900, Brazil 2 Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), Santa Maria, RS 97105-900, Brazil 3 Franciscan University Center (UNIFRA), Santa Maria, RS 97010-032, Brazil
* Author to whom correspondence should be addressed.
Received: 21 May 2013; in revised form: 9 July 2013 / Accepted: 22 July 2013 / Published: 31 July 2013
(This article belongs to the Section Natural Products)
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Abstract: Syzygium jambos and Solanum guaraniticum are both employed in Brazil as medicinal plants, even though their potential toxicity is not well established and they are frequently misused. The aim of this study was investigate the effect of the aqueous leaf extracts of both plants on δ-aminolevulinate dehydratase (δ-ALA-D) and acetylcholinesterase (AChE) activities and the antioxidant action against oxidative damage induced by sodium nitroprusside in rats, using in vitro assays. In addition, the presence of gallic, caffeic and chlorogenic acids, as well as rutin, quercetin and kaempferol as bioactive compounds in the extracts was identified by HPLC and their levels quantified. The antioxidant activities of both extracts were assessed by their capabilities to scavenge nitric oxide and to inhibit lipid peroxidation. Only Syzygium jambos presented thiol-peroxidase-like activity. Although neither extract affected the AChE activity, the aqueous extract of Solanum guaraniticum inhibited brain δ-ALA-D activity, suggesting a possible impairment effect on the central nervous system. Our results showed that both extracts exhibited efficient free radical scavenger activity and are an interesting source of bioactive compounds, justifying their use in folk medicine, although Solanum guaraniticum extract could have neurotoxicity properties and we therefore suggest that its use should be restricted to ensure the health of the population.
Keywords: Solanum guaraniticum; Syzygium jambos; δ-aminolevulinate dehydratase; lipid peroxidation; induced oxidative stress

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MDPI and ACS Style

Bonfanti, G.; Bitencourt, P.R.; Bona, K.S.; Silva, P.S.; Jantsch, L.B.; Pigatto, A.S.; Boligon, A.; Athayde, M.L.; Gonçalves, T.L.; Moretto, M.B. Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats. Molecules 2013, 18, 9179-9194.

AMA Style

Bonfanti G, Bitencourt PR, Bona KS, Silva PS, Jantsch LB, Pigatto AS, Boligon A, Athayde ML, Gonçalves TL, Moretto MB. Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats. Molecules. 2013; 18(8):9179-9194.

Chicago/Turabian Style

Bonfanti, Gabriela; Bitencourt, Paula R.; Bona, Karine S.; Silva, Priscila S.; Jantsch, Letícia B.; Pigatto, Aline S.; Boligon, Aline; Athayde, Margareth L.; Gonçalves, Thissiane L.; Moretto, Maria B. 2013. "Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats." Molecules 18, no. 8: 9179-9194.

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