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Molecules 2013, 18(8), 9163-9178; doi:10.3390/molecules18089163
Article

Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

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Received: 25 June 2013; in revised form: 24 July 2013 / Accepted: 25 July 2013 / Published: 31 July 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract: The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
Keywords: praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, W.-L.; Song, L.-J.; Chen, X.; Yin, X.-R.; Fan, W.-H.; Wang, G.-P.; Yu, C.-X.; Feng, B. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules 2013, 18, 9163-9178.

AMA Style

Wang W-L, Song L-J, Chen X, Yin X-R, Fan W-H, Wang G-P, Yu C-X, Feng B. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules. 2013; 18(8):9163-9178.

Chicago/Turabian Style

Wang, Wen-Long; Song, Li-Jun; Chen, Xia; Yin, Xu-Ren; Fan, Wen-Hua; Wang, Gu-Ping; Yu, Chuan-Xin; Feng, Bainian. 2013. "Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum." Molecules 18, no. 8: 9163-9178.



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