Next Article in Journal
Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats
Previous Article in Journal
Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
Molecules 2013, 18(8), 9163-9178; doi:10.3390/molecules18089163
Article

Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

1,2,†
,
3,†
,
1
,
3
,
2
,
1
,
3,*  and 1,2,*
1 School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China 2 Jiangshu Alpha Biopharmaceuticals, Inc., Wuxi 214122, China 3 Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 25 June 2013 / Revised: 24 July 2013 / Accepted: 25 July 2013 / Published: 31 July 2013
(This article belongs to the Section Medicinal Chemistry)
Download PDF [626 KB, uploaded 18 June 2014]

Abstract

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
Keywords: praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease praziquantel derivatives; antischistosomal activity; Schistosoma japonicum; neglected tropical disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Wang, W.-L.; Song, L.-J.; Chen, X.; Yin, X.-R.; Fan, W.-H.; Wang, G.-P.; Yu, C.-X.; Feng, B. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules 2013, 18, 9163-9178.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert