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Molecules 2013, 18(7), 8550-8562; doi:10.3390/molecules18078550

Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives

1
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
2
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
*
Author to whom correspondence should be addressed.
Received: 22 May 2013 / Revised: 19 June 2013 / Accepted: 20 June 2013 / Published: 19 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Tyrosinase enzyme is a monophenol monoxygenase enzyme, which plays an important role in human as a rate limiting step enzyme for different specific metabolic pathways, as well as its useful application in industry and agriculture. So this study was carried out to test the effect of newly prepared compounds containing 1,3,4-oxadiazoles with different substituted groups on tyrosinase enzyme activity, hoping to use them in the treatment of some diseases arising from tyrosinase activity disorders such as Parkinson’s disease, schizophrenia, autism, attention deficit, hyperactivity disorder, and cancer.
Keywords: carbohydrazide; oxadiazole; triazole; tyrosinase carbohydrazide; oxadiazole; triazole; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

El Sadek, M.M.; Hassan, S.Y.; Abdelwahab, H.E.; Yacout, G.A. Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives. Molecules 2013, 18, 8550-8562.

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