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Molecules 2013, 18(7), 8550-8562; doi:10.3390/molecules18078550

Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives

1,* , 1
Received: 22 May 2013 / Revised: 19 June 2013 / Accepted: 20 June 2013 / Published: 19 July 2013
(This article belongs to the Section Organic Synthesis)
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Tyrosinase enzyme is a monophenol monoxygenase enzyme, which plays an important role in human as a rate limiting step enzyme for different specific metabolic pathways, as well as its useful application in industry and agriculture. So this study was carried out to test the effect of newly prepared compounds containing 1,3,4-oxadiazoles with different substituted groups on tyrosinase enzyme activity, hoping to use them in the treatment of some diseases arising from tyrosinase activity disorders such as Parkinson’s disease, schizophrenia, autism, attention deficit, hyperactivity disorder, and cancer.
Keywords: carbohydrazide; oxadiazole; triazole; tyrosinase carbohydrazide; oxadiazole; triazole; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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El Sadek, M.M.; Hassan, S.Y.; Abdelwahab, H.E.; Yacout, G.A. Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives. Molecules 2013, 18, 8550-8562.

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