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Molecules 2013, 18(7), 7751-7760; doi:10.3390/molecules18077751

Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity

1,2, 1, 3, 1, 1, 1,2 and 1,*
1 School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China 2 Department of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Hutuo Road, Fuzhou 350108, China 3 Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
* Author to whom correspondence should be addressed.
Received: 20 May 2013 / Revised: 25 June 2013 / Accepted: 25 June 2013 / Published: 3 July 2013
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Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-D-glucopyranoside (5), quercetin- 3-O-β-D-glucopyranoside (6), scutellarein-7-O-β-D-glucoside (7) and api-genin-7-O-β-D- glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.
Keywords: Gnaphalium affine; phenolic glycosides; anti-complementary activity Gnaphalium affine; phenolic glycosides; anti-complementary activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, J.; Huang, D.; Chen, W.; Xi, Z.; Chen, C.; Huang, G.; Sun, L. Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity. Molecules 2013, 18, 7751-7760.

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