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Molecules 2013, 18(7), 7751-7760; doi:10.3390/molecules18077751

Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity

1,2, 1, 3, 1, 1, 1,2 and 1,*
1 School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China 2 Department of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Hutuo Road, Fuzhou 350108, China 3 Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
* Author to whom correspondence should be addressed.
Received: 20 May 2013 / Revised: 25 June 2013 / Accepted: 25 June 2013 / Published: 3 July 2013
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Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-D-glucopyranoside (5), quercetin- 3-O-β-D-glucopyranoside (6), scutellarein-7-O-β-D-glucoside (7) and api-genin-7-O-β-D- glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.
Keywords: Gnaphalium affine; phenolic glycosides; anti-complementary activity Gnaphalium affine; phenolic glycosides; anti-complementary activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, J.; Huang, D.; Chen, W.; Xi, Z.; Chen, C.; Huang, G.; Sun, L. Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity. Molecules 2013, 18, 7751-7760.

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