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Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, El-Messalah, Alexandria 21521, Egypt
* Author to whom correspondence should be addressed.
Received: 31 May 2013; in revised form: 18 June 2013 / Accepted: 21 June 2013 / Published: 3 July 2013
Abstract: Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various p-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984–0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2–200 mg mL−1. The limits of detection ranged from 0.41 to 12.24 mg mL−1. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54–100.46 ± 1.58–1.82%. The results were compared favorably with the reported method. The proposed methods are practical and valuable for routine application in quality control laboratories for determination of ROS-Ca in its bulk form and tablets.
Keywords: atherosclerosis; cholesterol; rosuvastatin calcium; charge-transfer complexes; spectrophotometry; pharmaceutical analysis
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Alzoman, N.Z.; Sultan, M.A.; Maher, H.M.; Alshehri, M.M.; Wani, T.A.; Darwish, I.A. Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors. Molecules 2013, 18, 7711-7725.
Alzoman NZ, Sultan MA, Maher HM, Alshehri MM, Wani TA, Darwish IA. Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors. Molecules. 2013; 18(7):7711-7725.
Alzoman, Nourah Z.; Sultan, Maha A.; Maher, Hadir M.; Alshehri, Mona M.; Wani, Tanveer A.; Darwish, Ibrahim A. 2013. "Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors." Molecules 18, no. 7: 7711-7725.