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Molecules 2013, 18(7), 7711-7725; doi:10.3390/molecules18077711
Article

Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors

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Received: 31 May 2013; in revised form: 18 June 2013 / Accepted: 21 June 2013 / Published: 3 July 2013
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Abstract: Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various p-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984–0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2–200 mg mL−1. The limits of detection ranged from 0.41 to 12.24 mg mL−1. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54–100.46 ± 1.58–1.82%. The results were compared favorably with the reported method. The proposed methods are practical and valuable for routine application in quality control laboratories for determination of ROS-Ca in its bulk form and tablets.
Keywords: atherosclerosis; cholesterol; rosuvastatin calcium; charge-transfer complexes; spectrophotometry; pharmaceutical analysis atherosclerosis; cholesterol; rosuvastatin calcium; charge-transfer complexes; spectrophotometry; pharmaceutical analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alzoman, N.Z.; Sultan, M.A.; Maher, H.M.; Alshehri, M.M.; Wani, T.A.; Darwish, I.A. Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors. Molecules 2013, 18, 7711-7725.

AMA Style

Alzoman NZ, Sultan MA, Maher HM, Alshehri MM, Wani TA, Darwish IA. Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors. Molecules. 2013; 18(7):7711-7725.

Chicago/Turabian Style

Alzoman, Nourah Z.; Sultan, Maha A.; Maher, Hadir M.; Alshehri, Mona M.; Wani, Tanveer A.; Darwish, Ibrahim A. 2013. "Analytical Study for the Charge-Transfer Complexes of Rosuvastatin Calcium with π-Acceptors." Molecules 18, no. 7: 7711-7725.



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