Next Article in Journal
Hepatotoxicity Evaluation of Aqueous Extract from Scutia buxifolia
Previous Article in Journal
Characterization of Total Phenolic Constituents from the Stems of Spatholobus suberectus Using LC-DAD-MSn and Their Inhibitory Effect on Human Neutrophil Elastase Activity
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(7), 7557-7569; doi:10.3390/molecules18077557

New 7-[4-(4-(un)Substituted)piperazine-1-carbonyl]- piperazin-1-yl] Derivatives of Fluoroquinolone: Synthesis and Antimicrobial Evaluation

1
School of Pharmacy, National Defense Medical Center, 161 Min-Chuan East Road, Section 6, Taipei 114, Taiwan
2
Department of Microbiology and Immunology, National Defense Medical Center, 161 Min-Chuan East Road, Section 6, Taipei 114, Taiwan
*
Author to whom correspondence should be addressed.
Received: 5 June 2013 / Revised: 26 June 2013 / Accepted: 26 June 2013 / Published: 27 June 2013
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [265 KB, uploaded 18 June 2014]   |  

Abstract

Fluoroquinolones have been a class of important synthetic antimicrobial agents broadly and effectively used in clinic for infectious diseases. In this study, the synthesis of a range of fluoroquinolone derivatives with 4-(carbopiperazin-1-yl)piperazinyl moieties at the C7 position and their inhibition of bacterial pathogens commonly disseminated in hospital environment were described. The results indicated that a 7-[4-(4-(benzoyl)carbopiperazin-1-yl)]piperazinyl derivative 5h and two 7-[4-(4- (benzenesulfonyl)carbopiperazin-1-yl)]piperazinyl derivatives 5k and 5l showed more promising growth inhibition of ciprofloxacin-resistant P. aeruginosa (CRPA) with MIC values as low as 16 mg/mL which is 16-fold more potent than ciprofloxacin, while most of other derivatives maintained potency against methicillin-resistant Staphylococcus aureus (MRSA). View Full-Text
Keywords: antimicrobial agents; ciprofloxacin; ciprofloxacin-resistant Pseudomonas aeruginosa; methicillin-resistant Staphylococcus aureus antimicrobial agents; ciprofloxacin; ciprofloxacin-resistant Pseudomonas aeruginosa; methicillin-resistant Staphylococcus aureus
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, P.-T.; Lin, W.-P.; Lee, A.-R.; Hu, M.-K. New 7-[4-(4-(un)Substituted)piperazine-1-carbonyl]- piperazin-1-yl] Derivatives of Fluoroquinolone: Synthesis and Antimicrobial Evaluation. Molecules 2013, 18, 7557-7569.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top