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Molecules 2013, 18(6), 6663-6678; doi:10.3390/molecules18066663
Article

Acetylcholinesterase Inhibition and in Vitro and in Vivo Antioxidant Activities of Ganoderma lucidum Grown on Germinated Brown Rice

,
 and *
Department of Applied Biochemistry, College of Biomedical and Health Science, Research Institute of Inflammatory Diseases, Konkuk University, Chungju 380-701, Korea
* Author to whom correspondence should be addressed.
Received: 16 May 2013 / Revised: 31 May 2013 / Accepted: 3 June 2013 / Published: 7 June 2013
(This article belongs to the Section Metabolites)
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Abstract

In this study, the acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice (GLBR) were evaluated. In antioxidant assays in vitro, GLBR was found to have strong metal chelating activity, DPPH, ABTS, hydroxyl and superoxide radical scavenging activity. Cell-based antioxidant methods were used, including lipid peroxidation on brain homogenate and AAPH-induced erythrocyte haemolysis. In antioxidant assays in vivo, mice were administered with GLBR and this significantly enhanced the activities of antioxidant enzymes in the mice sera, livers and brains. The amount of total phenolic and flavonoid compounds were 43.14 mg GAE/g and 13.36 mg CE/g dry mass, respectively. GLBR also exhibited acetylcholinesterase inhibitory activity. In addition, HPLC analyses of GLBR extract revealed the presence of different phenolic compounds. These findings demonstrate the remarkable potential of GLBR extract as valuable source of antioxidants which exhibit interesting acetylcholinesterase inhibitory activity.
Keywords: Ganoderma lucidum; acetylcholinesterase inhibition; antioxidant potential; cellular antioxidant activity; anti-hemolysis activity Ganoderma lucidum; acetylcholinesterase inhibition; antioxidant potential; cellular antioxidant activity; anti-hemolysis activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hasnat, M.A.; Pervin, M.; Lim, B.O. Acetylcholinesterase Inhibition and in Vitro and in Vivo Antioxidant Activities of Ganoderma lucidum Grown on Germinated Brown Rice. Molecules 2013, 18, 6663-6678.

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