Abstract: This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
Keywords: microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan
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Lin, Y.-S.; Yang, C.-H.; Wu, C.-T.; Grumezescu, A.M.; Wang, C.-Y.; Hsieh, W.-C.; Chen, S.-Y.; Huang, K.-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules 2013, 18, 6521-6531.
Lin Y-S, Yang C-H, Wu C-T, Grumezescu AM, Wang C-Y, Hsieh W-C, Chen S-Y, Huang K-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules. 2013; 18(6):6521-6531.
Lin, Yung-Sheng; Yang, Chih-Hui; Wu, Chin-Tung; Grumezescu, Alexandru M.; Wang, Chih-Yu; Hsieh, Wan-Chen; Chen, Szu-Yu; Huang, Keng-Shiang. 2013. "A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation." Molecules 18, no. 6: 6521-6531.