Next Article in Journal / Special Issue
Isocyanate-Functionalized Chitin and Chitosan as Gelling Agents of Castor Oil
Previous Article in Journal
The Development, Physicochemical Characterisation and in Vitro Drug Release Studies of Pectinate Gel Beads Containing Thai Mango Seed Kernel Extract
Previous Article in Special Issue
Mercury(II) Removal with Modified Magnetic Chitosan Adsorbents
Molecules 2013, 18(6), 6521-6531; doi:10.3390/molecules18066521
Article

A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation

1
, 2
, 3
, 4
, 5
, 2
, 2
 and 6,*
1 Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan 2 Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan 3 Department of Computer Science and Information Engineering, Providence University, Taichung 43301, Taiwan 4 Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest 011061, Romania 5 Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan 6 The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 April 2013 / Revised: 25 May 2013 / Accepted: 29 May 2013 / Published: 3 June 2013
(This article belongs to the Special Issue Chitins and Chitosans)
Download PDF [1997 KB, uploaded 18 June 2014]

Abstract

This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
Keywords: microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Lin, Y.-S.; Yang, C.-H.; Wu, C.-T.; Grumezescu, A.M.; Wang, C.-Y.; Hsieh, W.-C.; Chen, S.-Y.; Huang, K.-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules 2013, 18, 6521-6531.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert