Molecules 2013, 18(6), 6521-6531; doi:10.3390/molecules18066521
Article

A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation

1 Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan 2 Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan 3 Department of Computer Science and Information Engineering, Providence University, Taichung 43301, Taiwan 4 Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest 011061, Romania 5 Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan 6 The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 April 2013; in revised form: 25 May 2013 / Accepted: 29 May 2013 / Published: 3 June 2013
(This article belongs to the Special Issue Chitins and Chitosans)
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Abstract: This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
Keywords: microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan

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MDPI and ACS Style

Lin, Y.-S.; Yang, C.-H.; Wu, C.-T.; Grumezescu, A.M.; Wang, C.-Y.; Hsieh, W.-C.; Chen, S.-Y.; Huang, K.-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules 2013, 18, 6521-6531.

AMA Style

Lin Y-S, Yang C-H, Wu C-T, Grumezescu AM, Wang C-Y, Hsieh W-C, Chen S-Y, Huang K-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules. 2013; 18(6):6521-6531.

Chicago/Turabian Style

Lin, Yung-Sheng; Yang, Chih-Hui; Wu, Chin-Tung; Grumezescu, Alexandru M.; Wang, Chih-Yu; Hsieh, Wan-Chen; Chen, Szu-Yu; Huang, Keng-Shiang. 2013. "A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation." Molecules 18, no. 6: 6521-6531.

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