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A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation
Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan
Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan
Department of Computer Science and Information Engineering, Providence University, Taichung 43301, Taiwan
Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest 011061, Romania
Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 April 2013; in revised form: 25 May 2013 / Accepted: 29 May 2013 / Published: 3 June 2013
Abstract: This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
Keywords: microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan
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MDPI and ACS Style
Lin, Y.-S.; Yang, C.-H.; Wu, C.-T.; Grumezescu, A.M.; Wang, C.-Y.; Hsieh, W.-C.; Chen, S.-Y.; Huang, K.-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules 2013, 18, 6521-6531.
Lin Y-S, Yang C-H, Wu C-T, Grumezescu AM, Wang C-Y, Hsieh W-C, Chen S-Y, Huang K-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules. 2013; 18(6):6521-6531.
Lin, Yung-Sheng; Yang, Chih-Hui; Wu, Chin-Tung; Grumezescu, Alexandru M.; Wang, Chih-Yu; Hsieh, Wan-Chen; Chen, Szu-Yu; Huang, Keng-Shiang. 2013. "A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation." Molecules 18, no. 6: 6521-6531.