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Molecules 2013, 18(6), 6521-6531; doi:10.3390/molecules18066521
Article

A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation

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Received: 17 April 2013; in revised form: 25 May 2013 / Accepted: 29 May 2013 / Published: 3 June 2013
(This article belongs to the Special Issue Chitins and Chitosans)
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Abstract: This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
Keywords: microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lin, Y.-S.; Yang, C.-H.; Wu, C.-T.; Grumezescu, A.M.; Wang, C.-Y.; Hsieh, W.-C.; Chen, S.-Y.; Huang, K.-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules 2013, 18, 6521-6531.

AMA Style

Lin Y-S, Yang C-H, Wu C-T, Grumezescu AM, Wang C-Y, Hsieh W-C, Chen S-Y, Huang K-S. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation. Molecules. 2013; 18(6):6521-6531.

Chicago/Turabian Style

Lin, Yung-Sheng; Yang, Chih-Hui; Wu, Chin-Tung; Grumezescu, Alexandru M.; Wang, Chih-Yu; Hsieh, Wan-Chen; Chen, Szu-Yu; Huang, Keng-Shiang. 2013. "A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation." Molecules 18, no. 6: 6521-6531.


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