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Molecules 2013, 18(5), 6092-6100; doi:10.3390/molecules18056092
Article

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

1,* , 1
 and
2
1 Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia, Carrera 53 n 61-30., A.A. 1226, Medellín, Colombia 2 Departament de Productes Naturals, Facultat de Farmàcia, Universitat de Barcelona, Avn. Joan XXIII s/n, Barcelona 08028, Spain
* Author to whom correspondence should be addressed.
Received: 3 March 2013 / Revised: 25 April 2013 / Accepted: 10 May 2013 / Published: 22 May 2013
(This article belongs to the Section Natural Products)
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Abstract

Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.
Keywords: Garcinia madruno; Clusiaceae; bioflavonoids; LDL-antioxidant Garcinia madruno; Clusiaceae; bioflavonoids; LDL-antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Osorio, E.; Londoño, J.; Bastida, J. Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno. Molecules 2013, 18, 6092-6100.

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