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Molecules 2013, 18(5), 6092-6100; doi:10.3390/molecules18056092
Article

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

1,* , 1
 and
2
Received: 3 March 2013 / Revised: 25 April 2013 / Accepted: 10 May 2013 / Published: 22 May 2013
(This article belongs to the Section Metabolites)
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Abstract

Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.
Keywords: Garcinia madruno; Clusiaceae; bioflavonoids; LDL-antioxidant Garcinia madruno; Clusiaceae; bioflavonoids; LDL-antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Osorio, E.; Londoño, J.; Bastida, J. Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno. Molecules 2013, 18, 6092-6100.

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