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Molecules 2013, 18(5), 6021-6034; doi:10.3390/molecules18056021
Article

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars

, , ,  and *
Received: 7 May 2013 / Revised: 15 May 2013 / Accepted: 17 May 2013 / Published: 21 May 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars.
Keywords: aldohexose-derived cyclic nitrones; synthesis; piperidine iminosugars aldohexose-derived cyclic nitrones; synthesis; piperidine iminosugars
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, H.; Zhao, W.-B.; Zhu, J.-S.; Jia, Y.-M.; Yu, C.-Y. An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars. Molecules 2013, 18, 6021-6034.

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