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Molecules 2013, 18(5), 5723-5735; doi:10.3390/molecules18055723
Article

Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain

1
, 2
, 1
, 1
, 1
 and 1,*
1 School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China 2 Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China
* Author to whom correspondence should be addressed.
Received: 11 April 2013 / Revised: 9 May 2013 / Accepted: 10 May 2013 / Published: 16 May 2013
(This article belongs to the Section Metabolites)
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Abstract

Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus.
Keywords: citrinin; Penicillium sp. ML226; new metabolites; marine fungus citrinin; Penicillium sp. ML226; new metabolites; marine fungus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, M.L.; Lu, C.H.; Xu, Q.Y.; Song, S.Y.; Hu, Z.Y.; Zheng, Z.H. Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain. Molecules 2013, 18, 5723-5735.

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