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Molecules 2013, 18(5), 5723-5735; https://doi.org/10.3390/molecules18055723

Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain

1
School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China
2
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China
*
Author to whom correspondence should be addressed.
Received: 11 April 2013 / Revised: 9 May 2013 / Accepted: 10 May 2013 / Published: 16 May 2013
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus. View Full-Text
Keywords: citrinin; Penicillium sp. ML226; new metabolites; marine fungus citrinin; Penicillium sp. ML226; new metabolites; marine fungus
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Wang, M.L.; Lu, C.H.; Xu, Q.Y.; Song, S.Y.; Hu, Z.Y.; Zheng, Z.H. Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain. Molecules 2013, 18, 5723-5735.

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