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Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain
School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China
* Author to whom correspondence should be addressed.
Received: 11 April 2013; in revised form: 9 May 2013 / Accepted: 10 May 2013 / Published: 16 May 2013
Abstract: Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus.
Keywords: citrinin; Penicillium sp. ML226; new metabolites; marine fungus
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Cite This Article
MDPI and ACS Style
Wang, M.L.; Lu, C.H.; Xu, Q.Y.; Song, S.Y.; Hu, Z.Y.; Zheng, Z.H. Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain. Molecules 2013, 18, 5723-5735.
Wang ML, Lu CH, Xu QY, Song SY, Hu ZY, Zheng ZH. Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain. Molecules. 2013; 18(5):5723-5735.
Wang, Mei L.; Lu, Chun H.; Xu, Qing Y.; Song, Si Y.; Hu, Zhi Y.; Zheng, Zhong H. 2013. "Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain." Molecules 18, no. 5: 5723-5735.