Molecules 2013, 18(5), 5697-5705; doi:10.3390/molecules18055697

A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines

1,†,* email, 1,†email, 1email and 2,* email
Received: 19 April 2013; in revised form: 8 May 2013 / Accepted: 10 May 2013 / Published: 16 May 2013
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff’s base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.
Keywords: multi-component reaction; heterocyclic compounds; imidazo[4,5-g]-quinazoline; structure determination; hetero Diels-Alder reaction
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MDPI and ACS Style

Li, L.; Zhang, Q.; Liu, B.; Liu, G. A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines. Molecules 2013, 18, 5697-5705.

AMA Style

Li L, Zhang Q, Liu B, Liu G. A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines. Molecules. 2013; 18(5):5697-5705.

Chicago/Turabian Style

Li, Li; Zhang, Qianqian; Liu, Bo; Liu, Gang. 2013. "A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines." Molecules 18, no. 5: 5697-5705.

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