Molecules 2013, 18(5), 5142-5154; doi:10.3390/molecules18055142
Article

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

1 State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China 2 Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610072, China 3 Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 April 2013; in revised form: 26 April 2013 / Accepted: 27 April 2013 / Published: 3 May 2013
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Abstract: An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
Keywords: multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole

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MDPI and ACS Style

He, J.; Ouyang, G.; Yuan, Z.; Tong, R.; Shi, J.; Ouyang, L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules 2013, 18, 5142-5154.

AMA Style

He J, Ouyang G, Yuan Z, Tong R, Shi J, Ouyang L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules. 2013; 18(5):5142-5154.

Chicago/Turabian Style

He, Jun; Ouyang, Guang; Yuan, Zhixiang; Tong, Rongsheng; Shi, Jianyou; Ouyang, Liang. 2013. "A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction." Molecules 18, no. 5: 5142-5154.

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