Molecules 2013, 18(5), 5142-5154; doi:10.3390/molecules18055142
Article

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

Received: 3 April 2013; in revised form: 26 April 2013 / Accepted: 27 April 2013 / Published: 3 May 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
Keywords: multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole
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MDPI and ACS Style

He, J.; Ouyang, G.; Yuan, Z.; Tong, R.; Shi, J.; Ouyang, L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules 2013, 18, 5142-5154.

AMA Style

He J, Ouyang G, Yuan Z, Tong R, Shi J, Ouyang L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules. 2013; 18(5):5142-5154.

Chicago/Turabian Style

He, Jun; Ouyang, Guang; Yuan, Zhixiang; Tong, Rongsheng; Shi, Jianyou; Ouyang, Liang. 2013. "A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction." Molecules 18, no. 5: 5142-5154.

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