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Molecules 2013, 18(5), 5142-5154; doi:10.3390/molecules18055142
Article

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

1,†
,
2,†, 3, 2, 2,*  and 1,*
1 State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China 2 Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610072, China 3 Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 April 2013 / Revised: 26 April 2013 / Accepted: 27 April 2013 / Published: 3 May 2013
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Abstract

An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
Keywords: multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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He, J.; Ouyang, G.; Yuan, Z.; Tong, R.; Shi, J.; Ouyang, L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules 2013, 18, 5142-5154.

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