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Molecules 2013, 18(5), 5142-5154; doi:10.3390/molecules18055142
Article

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

1,†
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2,†, 3, 2, 2,*  and 1,*
Received: 3 April 2013 / Revised: 26 April 2013 / Accepted: 27 April 2013 / Published: 3 May 2013
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Abstract

An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
Keywords: multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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He, J.; Ouyang, G.; Yuan, Z.; Tong, R.; Shi, J.; Ouyang, L. A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction. Molecules 2013, 18, 5142-5154.

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