Molecules 2013, 18(5), 5059-5071; doi:10.3390/molecules18055059
Article

Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16

Received: 19 April 2013; in revised form: 22 April 2013 / Accepted: 26 April 2013 / Published: 29 April 2013
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
Keywords: virtual screening; piperazine derivative; piperidine derivatives; anti-EV71 activity; anti-CVA16 activity
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MDPI and ACS Style

Zhang, X.; Wang, H.; Li, Y.; Cao, R.; Zhong, W.; Zheng, Z.; Wang, G.; Xiao, J.; Li, S. Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16. Molecules 2013, 18, 5059-5071.

AMA Style

Zhang X, Wang H, Li Y, Cao R, Zhong W, Zheng Z, Wang G, Xiao J, Li S. Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16. Molecules. 2013; 18(5):5059-5071.

Chicago/Turabian Style

Zhang, Xian; Wang, Hongliang; Li, Yuhuan; Cao, Ruiyuan; Zhong, Wu; Zheng, Zhibing; Wang, Gang; Xiao, Junhai; Li, Song. 2013. "Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16." Molecules 18, no. 5: 5059-5071.

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