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Sesquiterpenoids from the Herb of Leonurus japonicus
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
Chengdu No.1 Pharmaceuticlco. Ltd., Chengdu 610031, Sichuan, China
* Authors to whom correspondence should be addressed.
Received: 10 April 2013; in revised form: 24 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
Abstract: Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
Keywords: Leonurus japonicus; sesquiterpenoids; bioactivities
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Xiong, L.; Zhou, Q.-M.; Peng, C.; Xie, X.-F.; Guo, L.; Li, X.-H.; Liu, J.; Liu, Z.-H.; Dai, O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules 2013, 18, 5051-5058.
Xiong L, Zhou Q-M, Peng C, Xie X-F, Guo L, Li X-H, Liu J, Liu Z-H, Dai O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules. 2013; 18(5):5051-5058.
Xiong, Liang; Zhou, Qin-Mei; Peng, Cheng; Xie, Xiao-Fang; Guo, Li; Li, Xiao-Hong; Liu, Juan; Liu, Zhao-Hua; Dai, Ou. 2013. "Sesquiterpenoids from the Herb of Leonurus japonicus." Molecules 18, no. 5: 5051-5058.