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Molecules 2013, 18(4), 4282-4292; doi:10.3390/molecules18044282

Antioxidant Activity and Proanthocyanidin Profile of Selliguea feei Rhizomes

1, 2, 2, 2 and 2,*
1 College of Bioscience & Biotechnology, Fuzhou University, Fuzhou 350108, Fujian, China 2 Department of Chemistry, National University of Singapore, 3 Science Dr. 3, Singapore 117543, Singapore
* Author to whom correspondence should be addressed.
Received: 20 March 2013 / Revised: 4 April 2013 / Accepted: 8 April 2013 / Published: 11 April 2013
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Proanthocyanidins from the rhizomes of Selliguea feei (PSFs) were solvent-extracted and fractionated by Sephadex LH-20 column chromatography to give a 2.42% isolated yield (dry matter basis). 1H-NMR spectroscopy revealed the mean degree of polymerization (mDP) to be 2.6. 13C-NMR analysis showed typical signals for afzelechin/epiafzelechin units. Clear peaks at 76 ppm and 84 ppm indicated that both stereoisomers (afzelechin/epiafzelechin) are present. In agreement with the NMR spectra, the ESI-MS spectrum indicated that PSFs are mainly monomers to trimers consisting of afzelechin/epiafzelechin units with A-type and B-type interflavanyl linkages. A trimer was purified and identified as demethylated selligueain B. Thiolysis confirmed the structure and the thiolytic products, methyl 2-[(2R, 3R, 4S)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)chroman-4-yl]acetate (1) and 4β-(carboxymethyl)sulphanylepiafzelechin-(2β→O→7,4β→8)-epiafzelechin methyl ester (2), were purified and characterized. Selligueain A, demethylated selligueain B, compounds 1 and 2 possess high antioxidant capacity at 1.18 × 104, 1.16 × 104, 0.95 × 104 and 1.29 × 104 µmol TE/g, respectively.
Keywords: Selliguea feei; proanthocyanidins; thiolysis; antioxidant activity Selliguea feei; proanthocyanidins; thiolysis; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fu, C.; Wang, H.; Ng, W.L.; Song, L.; Huang, D. Antioxidant Activity and Proanthocyanidin Profile of Selliguea feei Rhizomes. Molecules 2013, 18, 4282-4292.

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