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Molecules 2013, 18(4), 3917-3926; doi:10.3390/molecules18043917

Bisucaberin B, a Linear Hydroxamate Class Siderophore from the Marine Bacterium Tenacibaculum mesophilum

1,* , 2 and 2
Received: 16 February 2013 / Revised: 11 March 2013 / Accepted: 22 March 2013 / Published: 2 April 2013
(This article belongs to the Section Metabolites)
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A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in the Republic of Palau. Using spectroscopic and chemical methods, the structure of bisucaberin B (1) was clearly determined to be a linear dimeric hydroxamate class siderophore. Although compound 1 is an open form of the known macrocyclic dimer bisucaberin (2), and was previously described as a bacterial degradation product of desferrioxamine B (4), the present report is the first description of the de novo biosynthesis of 1. To the best of our knowledge, compound 1 is the first chemically characterized siderophore isolated from a bacterium belonging to the phylum Bacteroidetes.
Keywords: siderophore; Tenacibaculum mesophilum; macrocycle; bisucaberin siderophore; Tenacibaculum mesophilum; macrocycle; bisucaberin
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Fujita, M.J.; Nakano, K.; Sakai, R. Bisucaberin B, a Linear Hydroxamate Class Siderophore from the Marine Bacterium Tenacibaculum mesophilum. Molecules 2013, 18, 3917-3926.

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