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Molecules 2013, 18(4), 3917-3926; doi:10.3390/molecules18043917
Article

Bisucaberin B, a Linear Hydroxamate Class Siderophore from the Marine Bacterium Tenacibaculum mesophilum

1,* , 2 and 2
Received: 16 February 2013 / Revised: 11 March 2013 / Accepted: 22 March 2013 / Published: 2 April 2013
(This article belongs to the Section Metabolites)
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Abstract

A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in the Republic of Palau. Using spectroscopic and chemical methods, the structure of bisucaberin B (1) was clearly determined to be a linear dimeric hydroxamate class siderophore. Although compound 1 is an open form of the known macrocyclic dimer bisucaberin (2), and was previously described as a bacterial degradation product of desferrioxamine B (4), the present report is the first description of the de novo biosynthesis of 1. To the best of our knowledge, compound 1 is the first chemically characterized siderophore isolated from a bacterium belonging to the phylum Bacteroidetes.
Keywords: siderophore; Tenacibaculum mesophilum; macrocycle; bisucaberin siderophore; Tenacibaculum mesophilum; macrocycle; bisucaberin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fujita, M.J.; Nakano, K.; Sakai, R. Bisucaberin B, a Linear Hydroxamate Class Siderophore from the Marine Bacterium Tenacibaculum mesophilum. Molecules 2013, 18, 3917-3926.

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