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Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
* Author to whom correspondence should be addressed.
Received: 30 January 2013; in revised form: 28 February 2013 / Accepted: 5 March 2013 / Published: 15 March 2013
Abstract: A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).
Keywords: gorgonian coral; Carijoa sp.; pregnane steroid; cytotoxicity; antibacterial activity
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MDPI and ACS Style
Zhao, H.-Y.; Shao, C.-L.; Li, Z.-Y.; Han, L.; Cao, F.; Wang, C.-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules 2013, 18, 3458-3466.
Zhao H-Y, Shao C-L, Li Z-Y, Han L, Cao F, Wang C-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules. 2013; 18(3):3458-3466.
Zhao, Hong-Ying; Shao, Chang-Lun; Li, Zhi-Yong; Han, Lei; Cao, Fei; Wang, Chang-Yun. 2013. "Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.." Molecules 18, no. 3: 3458-3466.