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Molecules 2013, 18(3), 3458-3466; doi:10.3390/molecules18033458
Article

Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

1,2
,
1
,
2,* , 1
,
1
 and
1
1 Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China 2 Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
* Author to whom correspondence should be addressed.
Received: 30 January 2013 / Revised: 28 February 2013 / Accepted: 5 March 2013 / Published: 15 March 2013
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Abstract

A new pregnane steroid, 1, and three known analogues 24, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).
Keywords: gorgonian coral; Carijoa sp.; pregnane steroid; cytotoxicity; antibacterial activity gorgonian coral; Carijoa sp.; pregnane steroid; cytotoxicity; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhao, H.-Y.; Shao, C.-L.; Li, Z.-Y.; Han, L.; Cao, F.; Wang, C.-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules 2013, 18, 3458-3466.

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