Molecules 2013, 18(3), 3458-3466; doi:10.3390/molecules18033458
Article

Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

Received: 30 January 2013; in revised form: 28 February 2013 / Accepted: 5 March 2013 / Published: 15 March 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new pregnane steroid, 1, and three known analogues 24, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).
Keywords: gorgonian coral; Carijoa sp.; pregnane steroid; cytotoxicity; antibacterial activity
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MDPI and ACS Style

Zhao, H.-Y.; Shao, C.-L.; Li, Z.-Y.; Han, L.; Cao, F.; Wang, C.-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules 2013, 18, 3458-3466.

AMA Style

Zhao H-Y, Shao C-L, Li Z-Y, Han L, Cao F, Wang C-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules. 2013; 18(3):3458-3466.

Chicago/Turabian Style

Zhao, Hong-Ying; Shao, Chang-Lun; Li, Zhi-Yong; Han, Lei; Cao, Fei; Wang, Chang-Yun. 2013. "Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.." Molecules 18, no. 3: 3458-3466.

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