Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
AbstractA new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM). View Full-Text
- Supplementary File 1:
Supplementary Materials (PDF, 984 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Zhao, H.-Y.; Shao, C.-L.; Li, Z.-Y.; Han, L.; Cao, F.; Wang, C.-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules 2013, 18, 3458-3466.
Zhao H-Y, Shao C-L, Li Z-Y, Han L, Cao F, Wang C-Y. Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.. Molecules. 2013; 18(3):3458-3466.Chicago/Turabian Style
Zhao, Hong-Ying; Shao, Chang-Lun; Li, Zhi-Yong; Han, Lei; Cao, Fei; Wang, Chang-Yun. 2013. "Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.." Molecules 18, no. 3: 3458-3466.