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Volatiles, A Glutarimide Alkaloid and Antimicrobial Effects of Croton pullei (Euphorbiaceae)
Programa de Pós-graduação em Química, Universidade Federal do Pará, Av. Augusto Corrêa 01, 66075-110, Belém-PA, Brazil
Coordenação de Botânica, Museu Paraense Emílio Goeldi, CP 399, 66077-901, Belém-PA, Brazil
Programa de Pós-graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, 44036-900, Feira de Santana-BA, Brazil
Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Rodovia Ilhéus-Itabuna, s/n, 45662-900, Ilhéus-BA, Brazil
* Author to whom correspondence should be addressed.
Received: 14 December 2012; in revised form: 19 February 2013 / Accepted: 20 February 2013 / Published: 12 March 2013
Abstract: Chemical investigation of Croton pullei (Euphorbiaceae) collected in the Brazilian Amazon region was revisited. The chemical composition of the essential oils of leaves and stems was analyzed by GC/MS. It was found that both the oils comprise mainly terpenes, among which linalool was the major one (24.90 and 39.72%, respectively). Phytochemical investigation of the stem methanol extract led to the isolation of a new natural product from the glutarimide alkaloid group named N-[2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-acetamide, confirming that C. pullei is a rich source of this class of alkaloids. The hexane and methanol extracts of the stems of C. pullei showed moderate antibacterial and antifungal activity and the highest inhibition was observed when the methanol extract was tested against Staphylococcus aureus CCMB 262 and CCMB 263.
Keywords: Croton pullei; essential oils; glutarimide alkaloid; antibacterial activity; antifungal activity
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Peixoto, R.N.S.; Guilhon, G.M.S.P.; das Graças B. Zoghbi, M.; Araújo, I.S.; Uetanabaro, A.P.T.; Santos, L.S.; do S. B. Brasil, D. Volatiles, A Glutarimide Alkaloid and Antimicrobial Effects of Croton pullei (Euphorbiaceae). Molecules 2013, 18, 3195-3205.
Peixoto RNS, Guilhon GMSP, das Graças B. Zoghbi M, Araújo IS, Uetanabaro APT, Santos LS, do S. B. Brasil D. Volatiles, A Glutarimide Alkaloid and Antimicrobial Effects of Croton pullei (Euphorbiaceae). Molecules. 2013; 18(3):3195-3205.
Peixoto, Rosana N.S.; Guilhon, Giselle M.S.P.; das Graças B. Zoghbi, Maria; Araújo, Isabella S.; Uetanabaro, Ana P.T.; Santos, Lourivaldo S.; do S. B. Brasil, Davi. 2013. "Volatiles, A Glutarimide Alkaloid and Antimicrobial Effects of Croton pullei (Euphorbiaceae)." Molecules 18, no. 3: 3195-3205.