Molecules 2013, 18(3), 2864-2877; doi:10.3390/molecules18032864
Article

Synthesis and Cytotoxicity of Novel 10-Substituted Dihydroartemisinin Derivatives Containing N-Arylphenyl-ethenesulfonamide Groups

, , , , ,  and * email
Received: 4 December 2012; in revised form: 28 December 2012 / Accepted: 31 December 2012 / Published: 4 March 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The manuscript describes the synthesis of 10-substituted dihydroartemisinin derivatives containing N-aryl phenylethenesulfonamide groups and their in vitro anti-tumor activities against the HT-29, MDA-MB-231, U87MG, H460, A549 and HL-60 cancer cell lines and the normal WI-38 cell line. Most tested compounds showed enhanced cytotoxic activities and good selectivity toward the MDA-MB-231, HT-29 and HL-60 cell lines, with IC50 values in the single-digit μM range as compared with dihydroartemisinin (DHA), and all of them displayed less toxicity towards WI-38 cells. Among them, compounds 3c and 6c with trifluoromethoxy groups on the N-phenyl ring were found to be most active compounds against the six tested cancer cell lines.
Keywords: 10-substituted dihydroartemisinin derivatives; synthesis; anti-cancer
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MDPI and ACS Style

Liu, Y.; Liu, Z.; Shi, J.; Chen, H.; Mi, B.; Li, P.; Gong, P. Synthesis and Cytotoxicity of Novel 10-Substituted Dihydroartemisinin Derivatives Containing N-Arylphenyl-ethenesulfonamide Groups. Molecules 2013, 18, 2864-2877.

AMA Style

Liu Y, Liu Z, Shi J, Chen H, Mi B, Li P, Gong P. Synthesis and Cytotoxicity of Novel 10-Substituted Dihydroartemisinin Derivatives Containing N-Arylphenyl-ethenesulfonamide Groups. Molecules. 2013; 18(3):2864-2877.

Chicago/Turabian Style

Liu, Yajing; Liu, Zijian; Shi, Jiyue; Chen, Huimin; Mi, Bin; Li, Peng; Gong, Ping. 2013. "Synthesis and Cytotoxicity of Novel 10-Substituted Dihydroartemisinin Derivatives Containing N-Arylphenyl-ethenesulfonamide Groups." Molecules 18, no. 3: 2864-2877.

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