Next Article in Journal
Volatile Compounds in Dry Dog Foods and Their Influence on Sensory Aromatic Profile
Previous Article in Journal
Main Alkaloids of Peganum harmala L. and Their Different Effects on Dicot and Monocot Crops
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(3), 2635-2645; doi:10.3390/molecules18032635

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

Center of Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania
Research Center Oltchim, St. Uzinei 1, Ramnicu Vilcea 240050, Romania
Faculty of Pharmacy, "Ovidius" University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania
Author to whom correspondence should be addressed.
Received: 29 January 2013 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [176 KB, uploaded 18 June 2014]   |  


Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.
Keywords: pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dumitrascu, F.; Georgescu, E.; Georgescu, F.; Popa, M.M.; Dumitrescu, D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules 2013, 18, 2635-2645.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top