Molecules 2013, 18(3), 2635-2645; doi:10.3390/molecules18032635
Article

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

1 Center of Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania 2 Research Center Oltchim, St. Uzinei 1, Ramnicu Vilcea 240050, Romania 3 Faculty of Pharmacy, "Ovidius" University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania
* Author to whom correspondence should be addressed.
Received: 29 January 2013; in revised form: 18 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.
Keywords: pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition

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MDPI and ACS Style

Dumitrascu, F.; Georgescu, E.; Georgescu, F.; Popa, M.M.; Dumitrescu, D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules 2013, 18, 2635-2645.

AMA Style

Dumitrascu F, Georgescu E, Georgescu F, Popa MM, Dumitrescu D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules. 2013; 18(3):2635-2645.

Chicago/Turabian Style

Dumitrascu, Florea; Georgescu, Emilian; Georgescu, Florentina; Popa, Marcel M.; Dumitrescu, Denisa. 2013. "Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition." Molecules 18, no. 3: 2635-2645.

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