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Molecules 2013, 18(3), 2635-2645; doi:10.3390/molecules18032635
Article

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

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Received: 29 January 2013 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.
Keywords: pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dumitrascu, F.; Georgescu, E.; Georgescu, F.; Popa, M.M.; Dumitrescu, D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules 2013, 18, 2635-2645.

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