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Molecules 2013, 18(3), 2635-2645; doi:10.3390/molecules18032635

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

Center of Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania
Research Center Oltchim, St. Uzinei 1, Ramnicu Vilcea 240050, Romania
Faculty of Pharmacy, "Ovidius" University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania
Author to whom correspondence should be addressed.
Received: 29 January 2013 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Section Organic Synthesis)
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Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy. View Full-Text
Keywords: pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dumitrascu, F.; Georgescu, E.; Georgescu, F.; Popa, M.M.; Dumitrescu, D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules 2013, 18, 2635-2645.

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