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Molecules 2013, 18(3), 2598-2610; doi:10.3390/molecules18032598
Article

Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox

1,2,* , 3
,
1
,
3
,
3
,
4,*  and 1
1 Grupo de Investigación Productos Naturales Marinos, Facultad de Química Farmacéutica, Universidad de Antioquia, A.A 1226, Medellín, Colombia 2 Unidad de Investigación e Innovación, Humax Pharmaceutical S.A. Itagüí, Colombia 3 Grupo de Biotecnología Animal, Universidad Nacional de Colombia, Medellín, Colombia 4 Nice Institute of Chemistry – PCRE,UMR 7272 CNRS, University of Nice Sophia-Antipolis, Faculté des Sciences, Parc Valrose 06108 Nice, France
* Authors to whom correspondence should be addressed.
Received: 21 January 2013 / Revised: 7 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract

Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.
Keywords: Ectyoplasia ferox; marine sponge; saponins; urabosides; ulososides Ectyoplasia ferox; marine sponge; saponins; urabosides; ulososides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Colorado, J.; Muñoz, D.; Marquez, D.; Marquez, M.E.; Lopez, J.; Thomas, O.P.; Martinez, A. Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules 2013, 18, 2598-2610.

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