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Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox
Grupo de Investigación Productos Naturales Marinos, Facultad de Química Farmacéutica, Universidad de Antioquia, A.A 1226, Medellín, Colombia
Unidad de Investigación e Innovación, Humax Pharmaceutical S.A. Itagüí, Colombia
Grupo de Biotecnología Animal, Universidad Nacional de Colombia, Medellín, Colombia
Nice Institute of Chemistry – PCRE,UMR 7272 CNRS, University of Nice Sophia-Antipolis, Faculté des Sciences, Parc Valrose 06108 Nice, France
* Authors to whom correspondence should be addressed.
Received: 21 January 2013; in revised form: 7 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
Abstract: Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.
Keywords: Ectyoplasia ferox; marine sponge; saponins; urabosides; ulososides
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MDPI and ACS Style
Colorado, J.; Muñoz, D.; Marquez, D.; Marquez, M.E.; Lopez, J.; Thomas, O.P.; Martinez, A. Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules 2013, 18, 2598-2610.
Colorado J, Muñoz D, Marquez D, Marquez ME, Lopez J, Thomas OP, Martinez A. Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules. 2013; 18(3):2598-2610.
Colorado, Jhonny; Muñoz, Diana; Marquez, Diana; Marquez, Maria E.; Lopez, Juan; Thomas, Olivier P.; Martinez, Alejandro. 2013. "Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox." Molecules 18, no. 3: 2598-2610.