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Molecules 2013, 18(3), 2598-2610; doi:10.3390/molecules18032598
Article

Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox

1,2,* , 3
, 1
, 3
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, 4,*  and 1
Received: 21 January 2013; in revised form: 7 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract: Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.
Keywords: Ectyoplasia ferox; marine sponge; saponins; urabosides; ulososides Ectyoplasia ferox; marine sponge; saponins; urabosides; ulososides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Colorado, J.; Muñoz, D.; Marquez, D.; Marquez, M.E.; Lopez, J.; Thomas, O.P.; Martinez, A. Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules 2013, 18, 2598-2610.

AMA Style

Colorado J, Muñoz D, Marquez D, Marquez ME, Lopez J, Thomas OP, Martinez A. Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules. 2013; 18(3):2598-2610.

Chicago/Turabian Style

Colorado, Jhonny; Muñoz, Diana; Marquez, Diana; Marquez, Maria E.; Lopez, Juan; Thomas, Olivier P.; Martinez, Alejandro. 2013. "Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox." Molecules 18, no. 3: 2598-2610.



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