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Molecules 2013, 18(2), 2236-2242; doi:10.3390/molecules18022236

New Spiral γ-Lactone Enantiomers from the Plant Endophytic Fungus Pestalotiopsis foedan

College of Pharmaceutical Science, Hebei University, Baoding 071002, Hebei, China
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Author to whom correspondence should be addressed.
Received: 27 December 2012 / Revised: 20 January 2013 / Accepted: 22 January 2013 / Published: 11 February 2013
(This article belongs to the Section Natural Products)
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Abstract

(−)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1b showed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines.
Keywords: plant endophytic fungus; Pestalotiopsis foedan; foedanolide; cytotoxic activity plant endophytic fungus; Pestalotiopsis foedan; foedanolide; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, X.-L.; Li, Z.-Z. New Spiral γ-Lactone Enantiomers from the Plant Endophytic Fungus Pestalotiopsis foedan . Molecules 2013, 18, 2236-2242.

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