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Molecules 2013, 18(2), 1826-1843; doi:10.3390/molecules18021826
Review

Pharmacological Actions of Multi-Target-Directed Evodiamine

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Received: 14 December 2012 / Revised: 28 January 2013 / Accepted: 29 January 2013 / Published: 31 January 2013
(This article belongs to the Section Metabolites)
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Abstract

Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and themoregulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.
Keywords: evodiamine; bioactivity; mechanism; receptor binding evodiamine; bioactivity; mechanism; receptor binding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, H.; Jin, H.; Gong, W.; Wang, Z.; Liang, H. Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules 2013, 18, 1826-1843.

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