Molecules 2013, 18(2), 1826-1843; doi:10.3390/molecules18021826

Pharmacological Actions of Multi-Target-Directed Evodiamine

1 State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, China 2 The Second Affiliated Hospital, Baotou Medical College, Baotou 014030, China 3 State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China 4 The First Affiliated Hospital, Baotou Medical College, Baotou 014010, China
* Authors to whom correspondence should be addressed.
Received: 14 December 2012; in revised form: 28 January 2013 / Accepted: 29 January 2013 / Published: 31 January 2013
(This article belongs to the Section Natural Products)
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Abstract: Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and themoregulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.
Keywords: evodiamine; bioactivity; mechanism; receptor binding

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MDPI and ACS Style

Yu, H.; Jin, H.; Gong, W.; Wang, Z.; Liang, H. Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules 2013, 18, 1826-1843.

AMA Style

Yu H, Jin H, Gong W, Wang Z, Liang H. Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules. 2013; 18(2):1826-1843.

Chicago/Turabian Style

Yu, Hui; Jin, Hongwei; Gong, Wuzhuang; Wang, Zhanli; Liang, Huaping. 2013. "Pharmacological Actions of Multi-Target-Directed Evodiamine." Molecules 18, no. 2: 1826-1843.

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