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Pharmacological Actions of Multi-Target-Directed Evodiamine
State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, China
The Second Affiliated Hospital, Baotou Medical College, Baotou 014030, China
State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
The First Affiliated Hospital, Baotou Medical College, Baotou 014010, China
* Authors to whom correspondence should be addressed.
Received: 14 December 2012; in revised form: 28 January 2013 / Accepted: 29 January 2013 / Published: 31 January 2013
Abstract: Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and themoregulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.
Keywords: evodiamine; bioactivity; mechanism; receptor binding
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MDPI and ACS Style
Yu, H.; Jin, H.; Gong, W.; Wang, Z.; Liang, H. Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules 2013, 18, 1826-1843.
Yu H, Jin H, Gong W, Wang Z, Liang H. Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules. 2013; 18(2):1826-1843.
Yu, Hui; Jin, Hongwei; Gong, Wuzhuang; Wang, Zhanli; Liang, Huaping. 2013. "Pharmacological Actions of Multi-Target-Directed Evodiamine." Molecules 18, no. 2: 1826-1843.