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Molecules 2013, 18(2), 1819-1825; doi:10.3390/molecules18021819

Article

Two New Koumine-Type Indole Alkaloids from Gelsemium elegans Benth.

Mingxue Sun ^1,2 , Xiaoli Hou ¹ , Huanhuan Gao ¹ , Junsheng Guo ^2,*  and Kai Xiao ^1,*

¹ Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China ² Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China

* Authors to whom correspondence should be addressed.

Received: 27 December 2012; in revised form: 24 January 2013 / Accepted: 25 January 2013 / Published: 31 January 2013

(This article belongs to the Section Natural Products)

Download PDF Full-Text [640 KB, uploaded 31 January 2013 11:09 CET]

Abstract: Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds. The structures of the two novel compounds were elucidated by spectroscopic methods, including NMR, HR-ESI-MS, UV, IR, CD and molecular modeling. Compound 1 is the first instance of a koumine-type alkaloid with a carbonyl at the C-21 position, while compound 2 possesses a tetrahydrofuran ring located on C-20 and C-21.

Keywords: indole alkaloids; Gelsemium elegans Benth.; 21-oxokoumine; furanokoumine

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