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Molecules 2013, 18(2), 1762-1774; doi:10.3390/molecules18021762
Article

Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

1, 1,2, 2, 2, 2, 3, 1,2,*  and 1,*
Received: 13 November 2012; in revised form: 6 January 2013 / Accepted: 7 January 2013 / Published: 29 January 2013
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Abstract: The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
Keywords: cyclophane; macrocycle; iron; biomimetic; antioxidant cyclophane; macrocycle; iron; biomimetic; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Salazar-Medina, A.J.; Sugich-Miranda, R.; Teran-Cabanillas, E.; Hernández, J.; González-Aguilar, G.A.; Rudiño-Piñera, E.; Sotelo-Mundo, R.R.; Velázquez-Contreras, E.F. Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes. Molecules 2013, 18, 1762-1774.

AMA Style

Salazar-Medina AJ, Sugich-Miranda R, Teran-Cabanillas E, Hernández J, González-Aguilar GA, Rudiño-Piñera E, Sotelo-Mundo RR, Velázquez-Contreras EF. Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes. Molecules. 2013; 18(2):1762-1774.

Chicago/Turabian Style

Salazar-Medina, Alex J.; Sugich-Miranda, Rocío; Teran-Cabanillas, Eli; Hernández, Jesús; González-Aguilar, Gustavo A.; Rudiño-Piñera, Enrique; Sotelo-Mundo, Rogerio R.; Velázquez-Contreras, Enrique F. 2013. "Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes." Molecules 18, no. 2: 1762-1774.



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