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Molecules 2013, 18(2), 1762-1774; doi:10.3390/molecules18021762
Article

Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

1, 1,2, 2, 2, 2, 3, 1,2,*  and 1,*
1 Departamento de Investigación en Polímeros y Materiales (DIPM), Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130. Hermosillo Sonora 83000, Mexico 2 Centro de Investigación en Alimentación y Desarrollo (CIAD), A.C. Carretera a Ejido La Victoria Km 0.6, PO Box 1735, Hermosillo Sonora 83304, Mexico 3 Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (IBT-UNAM) Av. Universidad #2001, Col. Chamilpa, Cuernavaca, Morelos 62250, Mexico
* Authors to whom correspondence should be addressed.
Received: 13 November 2012 / Revised: 6 January 2013 / Accepted: 7 January 2013 / Published: 29 January 2013
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Abstract

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
Keywords: cyclophane; macrocycle; iron; biomimetic; antioxidant cyclophane; macrocycle; iron; biomimetic; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Salazar-Medina, A.J.; Sugich-Miranda, R.; Teran-Cabanillas, E.; Hernández, J.; González-Aguilar, G.A.; Rudiño-Piñera, E.; Sotelo-Mundo, R.R.; Velázquez-Contreras, E.F. Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes. Molecules 2013, 18, 1762-1774.

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