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Molecules 2013, 18(2), 1613-1625; doi:10.3390/molecules18021613

Article

Microwave-Assisted Improved Synthesis of Pyrrolo[2,3,4-kl]acridine and Dihydropyrrolo[2,3,4-kl]acridine Derivatives Catalyzed by Silica Sulfuric Acid

Chengpao Cao ^1,† , Changliang Xu ^2,† , Wei Lin ¹ , Xuemei Li ³ , Minghua Hu ¹ , Juxian Wang ² , Zhibin Huang ¹ , Daqing Shi ^1,*  and Yucheng Wang ^2,*

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China ² Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China ³ Center for Drug Evaluation, State Food and Drug Administration Office of Generic Drug Pharmaceutical Science, Beijing 100038, China ^† These authors contributed equally to this work.

* Authors to whom correspondence should be addressed.

Received: 29 November 2012; in revised form: 21 December 2012 / Accepted: 5 January 2013 / Published: 28 January 2013

Download PDF Full-Text [223 KB, uploaded 28 January 2013 10:30 CET]

Abstract: An improved synthesis of multifunctionalized pyrrolo[2,3,4-kl]acridine derivatives with different substituted patterns using silica sulfuric acid (SSA) as a heterogeneous catalyst under microwave irradiation conditions was developed. The reaction could be conducted by using readily available and inexpensive substrates within short periods of 12–15 min. under microwave irradiation. Compared with the conventional methods, the remarkable advantages of this method are milder reaction conditions, operational simplicity, higher yields, short reaction times, and an environmentally friendly procedure.

Keywords: pyrrolo[2,3,4-kl]acridine; silica sulfuric acid; microwave irradiation

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