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Molecules 2013, 18(11), 13623-13635; doi:10.3390/molecules181113623
Article

Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

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Received: 13 September 2013; in revised form: 24 October 2013 / Accepted: 29 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Organobismuth Chemistry)
Download PDF [263 KB, uploaded 18 June 2014]
Abstract: Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
Keywords: benzofuran; benzothiazole; β-amino acid ester; anti-TMV activity benzofuran; benzothiazole; β-amino acid ester; anti-TMV activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xiao, H.; Zheng, P.; Tang, C.; Xie, Y.; Wu, F.; Song, J.; Zhao, J.; Li, Z.; Li, M. Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates. Molecules 2013, 18, 13623-13635.

AMA Style

Xiao H, Zheng P, Tang C, Xie Y, Wu F, Song J, Zhao J, Li Z, Li M. Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates. Molecules. 2013; 18(11):13623-13635.

Chicago/Turabian Style

Xiao, Han; Zheng, Pengcheng; Tang, Chenghao; Xie, Ying; Wu, Fang; Song, Jie; Zhao, Jun; Li, Zhining; Li, Meichuan. 2013. "Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates." Molecules 18, no. 11: 13623-13635.


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