Molecules 2013, 18(11), 13623-13635; doi:10.3390/molecules181113623
Article

Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

1 Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China 2 School of Chemistry and Environmental Science, Guizhou Minzu University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 13 September 2013; in revised form: 24 October 2013 / Accepted: 29 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Organobismuth Chemistry)
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Abstract: Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
Keywords: benzofuran; benzothiazole; β-amino acid ester; anti-TMV activity

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MDPI and ACS Style

Xiao, H.; Zheng, P.; Tang, C.; Xie, Y.; Wu, F.; Song, J.; Zhao, J.; Li, Z.; Li, M. Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates. Molecules 2013, 18, 13623-13635.

AMA Style

Xiao H, Zheng P, Tang C, Xie Y, Wu F, Song J, Zhao J, Li Z, Li M. Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates. Molecules. 2013; 18(11):13623-13635.

Chicago/Turabian Style

Xiao, Han; Zheng, Pengcheng; Tang, Chenghao; Xie, Ying; Wu, Fang; Song, Jie; Zhao, Jun; Li, Zhining; Li, Meichuan. 2013. "Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates." Molecules 18, no. 11: 13623-13635.

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