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Molecules 2013, 18(11), 13623-13635; doi:10.3390/molecules181113623
Article

Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

1,2,* , 1
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1 Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China 2 School of Chemistry and Environmental Science, Guizhou Minzu University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 13 September 2013 / Revised: 24 October 2013 / Accepted: 29 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Organobismuth Chemistry)
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Abstract

Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
Keywords: benzofuran; benzothiazole; β-amino acid ester; anti-TMV activity benzofuran; benzothiazole; β-amino acid ester; anti-TMV activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xiao, H.; Zheng, P.; Tang, C.; Xie, Y.; Wu, F.; Song, J.; Zhao, J.; Li, Z.; Li, M. Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates. Molecules 2013, 18, 13623-13635.

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