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Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark
Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C 1871, Denmark
Physicochemical characterizations were performed by this author.
* Authors to whom correspondence should be addressed.
Received: 16 September 2013; in revised form: 15 October 2013 / Accepted: 19 October 2013 / Published: 1 November 2013
Abstract: Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.
Keywords: glycolipid synthesis; calorimetrics; biomimetic membranes; physiological conditions
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Hogendorf, W.F.J.; Jagalski, V.; Pomorski, T.G.; Bols, M.; Cárdenas, M.; Pedersen, C.M. Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids. Molecules 2013, 18, 13546-13573.
Hogendorf WFJ, Jagalski V, Pomorski TG, Bols M, Cárdenas M, Pedersen CM. Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids. Molecules. 2013; 18(11):13546-13573.
Hogendorf, Wouter F.J.; Jagalski, Vivien; Pomorski, Thomas G.; Bols, Mikael; Cárdenas, Marité; Pedersen, Christian M. 2013. "Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids." Molecules 18, no. 11: 13546-13573.