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Molecules 2013, 18(11), 13546-13573; doi:10.3390/molecules181113546
Article

Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids

1, 1,†, 2, 1, 1,*  and 1,*
Received: 16 September 2013; in revised form: 15 October 2013 / Accepted: 19 October 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Synthesis, Structure, Analysis and Properties of Glycolipids)
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Abstract: Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.
Keywords: glycolipid synthesis; calorimetrics; biomimetic membranes; physiological conditions glycolipid synthesis; calorimetrics; biomimetic membranes; physiological conditions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hogendorf, W.F.J.; Jagalski, V.; Pomorski, T.G.; Bols, M.; Cárdenas, M.; Pedersen, C.M. Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids. Molecules 2013, 18, 13546-13573.

AMA Style

Hogendorf WFJ, Jagalski V, Pomorski TG, Bols M, Cárdenas M, Pedersen CM. Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids. Molecules. 2013; 18(11):13546-13573.

Chicago/Turabian Style

Hogendorf, Wouter F.J.; Jagalski, Vivien; Pomorski, Thomas G.; Bols, Mikael; Cárdenas, Marité; Pedersen, Christian M. 2013. "Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids." Molecules 18, no. 11: 13546-13573.


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