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Molecules 2013, 18(10), 13027-13042; doi:10.3390/molecules181013027
Article

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

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Received: 10 September 2013; in revised form: 30 September 2013 / Accepted: 9 October 2013 / Published: 18 October 2013
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Abstract: A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are briefly discussed.
Keywords: ligustrazine; neuroprotective effect; cobalt chloride; PC12 cell; HE staining ligustrazine; neuroprotective effect; cobalt chloride; PC12 cell; HE staining
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, P.; Zhang, H.; Chu, F.; Xu, X.; Lin, J.; Chen, C.; Li, G.; Cheng, Y.; Wang, L.; Li, Q.; Zhang, Y.; Lei, H. Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells. Molecules 2013, 18, 13027-13042.

AMA Style

Wang P, Zhang H, Chu F, Xu X, Lin J, Chen C, Li G, Cheng Y, Wang L, Li Q, Zhang Y, Lei H. Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells. Molecules. 2013; 18(10):13027-13042.

Chicago/Turabian Style

Wang, Penglong; Zhang, Honggui; Chu, Fuhao; Xu, Xin; Lin, Jinxuan; Chen, Chunxiao; Li, Guoliang; Cheng, Yatao; Wang, Lin; Li, Qiang; Zhang, Yuzhong; Lei, Haimin. 2013. "Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells." Molecules 18, no. 10: 13027-13042.


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