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Molecules 2013, 18(10), 13027-13042; doi:10.3390/molecules181013027

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

1
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
2
Department of Pathology, Beijing University of Chinese Medicine, Beijing 100102, China
*
Authors to whom correspondence should be addressed.
Received: 10 September 2013 / Revised: 30 September 2013 / Accepted: 9 October 2013 / Published: 18 October 2013
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Abstract

A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are briefly discussed.
Keywords: ligustrazine; neuroprotective effect; cobalt chloride; PC12 cell; HE staining ligustrazine; neuroprotective effect; cobalt chloride; PC12 cell; HE staining
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, P.; Zhang, H.; Chu, F.; Xu, X.; Lin, J.; Chen, C.; Li, G.; Cheng, Y.; Wang, L.; Li, Q.; Zhang, Y.; Lei, H. Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells. Molecules 2013, 18, 13027-13042.

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