Next Article in Journal
Promising Low-Toxicity of Viologen-Phosphorus Dendrimers against Embryonic Mouse Hippocampal Cells
Previous Article in Journal
Qualitative and Quantitative Analysis of Andrographis paniculata by Rapid Resolution Liquid Chromatography/Time-of-Flight Mass Spectrometry
Molecules 2013, 18(10), 12208-12221; doi:10.3390/molecules181012208
Article

In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

1,2,* , 3,4, 1 and 1
Received: 1 September 2013 / Revised: 19 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Medicinal Chemistry)
Download PDF [250 KB, uploaded 18 June 2014]

Abstract

Anti-Candida activities of certain new oximes 4ad and their respective aromatic esters 5al are reported. The tested compounds 4ad and 5al exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
Keywords: synthesis; Mannich reaction; azoles; oxime esters; anti-Candida synthesis; Mannich reaction; azoles; oxime esters; anti-Candida
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Attia, M.I.; Zakaria, A.S.; Almutairi, M.S.; Ghoneim, S.W. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules 2013, 18, 12208-12221.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert