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Molecules 2013, 18(10), 12208-12221; doi:10.3390/molecules181012208
Article

In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

1,2,* , 3,4, 1 and 1
1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2 Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza 12622, Egypt 3 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4 Department of Microbiology, Faculty of Pharmacy, Alexandria University, Alexandria 21500, Egypt
* Author to whom correspondence should be addressed.
Received: 1 September 2013 / Revised: 19 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Anti-Candida activities of certain new oximes 4ad and their respective aromatic esters 5al are reported. The tested compounds 4ad and 5al exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
Keywords: synthesis; Mannich reaction; azoles; oxime esters; anti-Candida synthesis; Mannich reaction; azoles; oxime esters; anti-Candida
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Attia, M.I.; Zakaria, A.S.; Almutairi, M.S.; Ghoneim, S.W. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules 2013, 18, 12208-12221.

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