Molecules 2013, 18(10), 12208-12221; doi:10.3390/molecules181012208
Article

In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2 Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza 12622, Egypt 3 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4 Department of Microbiology, Faculty of Pharmacy, Alexandria University, Alexandria 21500, Egypt
* Author to whom correspondence should be addressed.
Received: 1 September 2013; in revised form: 19 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Medicinal Chemistry)
PDF Full-text Download PDF Full-Text [250 KB, uploaded 30 September 2013 10:01 CEST]
Abstract: Anti-Candida activities of certain new oximes 4ad and their respective aromatic esters 5al are reported. The tested compounds 4ad and 5al exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
Keywords: synthesis; Mannich reaction; azoles; oxime esters; anti-Candida

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Attia, M.I.; Zakaria, A.S.; Almutairi, M.S.; Ghoneim, S.W. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules 2013, 18, 12208-12221.

AMA Style

Attia MI, Zakaria AS, Almutairi MS, Ghoneim SW. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules. 2013; 18(10):12208-12221.

Chicago/Turabian Style

Attia, Mohamed I.; Zakaria, Azza S.; Almutairi, Maha S.; Ghoneim, Soraya W. 2013. "In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters." Molecules 18, no. 10: 12208-12221.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert