Molecules 2013, 18(10), 12208-12221; doi:10.3390/molecules181012208
Article

In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

Received: 1 September 2013; in revised form: 19 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Anti-Candida activities of certain new oximes 4ad and their respective aromatic esters 5al are reported. The tested compounds 4ad and 5al exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
Keywords: synthesis; Mannich reaction; azoles; oxime esters; anti-Candida
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MDPI and ACS Style

Attia, M.I.; Zakaria, A.S.; Almutairi, M.S.; Ghoneim, S.W. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules 2013, 18, 12208-12221.

AMA Style

Attia MI, Zakaria AS, Almutairi MS, Ghoneim SW. In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters. Molecules. 2013; 18(10):12208-12221.

Chicago/Turabian Style

Attia, Mohamed I.; Zakaria, Azza S.; Almutairi, Maha S.; Ghoneim, Soraya W. 2013. "In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters." Molecules 18, no. 10: 12208-12221.

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