Abstract: Lantadenes are pentacyclic triterpenoids present in the leaves of the plant Lantana camara. In the present study, in vitro antioxidant activity and free radical scavenging capacity of lantadene A was evaluated using established in vitro models such as ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH•), hydroxyl radical (OH•), nitric oxide radical (NO•), superoxide anion scavenging activities and ferrous ion chelating assay. Interestingly, lantadene A showed considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner when compared with the standard antioxidant in nitric oxide scavenging, superoxide anion radical scavenging and ferrous ion chelating assay. These findings show that the lantadene A possesses antioxidant activity with different mechanism of actions towards the different free radicals tested. Since lantadene A is a very popular drug in modern medicine, it is a promising candidate for use as an antioxidant and hepatoprotective agent.
Keywords: antioxidant activity; free radical; lantadene A; triterpenes
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Grace-Lynn, C.; Darah, I.; Chen, Y.; Latha, L.Y.; Jothy, S.L.; Sasidharan, S. In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants. Molecules 2012, 17, 11185-11198.
Grace-Lynn C, Darah I, Chen Y, Latha LY, Jothy SL, Sasidharan S. In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants. Molecules. 2012; 17(9):11185-11198.
Grace-Lynn, Chong; Darah, Ibrahim; Chen, Yeng; Latha, Lachimanan Yoga; Jothy, Subramanion L.; Sasidharan, Sreenivasan. 2012. "In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants." Molecules 17, no. 9: 11185-11198.