Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(9), 10893-10901; doi:10.3390/molecules170910893
Article

Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King

1,* , 1, 1 and 2
Received: 30 July 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 10 September 2012
(This article belongs to the Section Metabolites)
Download PDF [188 KB, uploaded 18 June 2014]
Abstract: The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8)-flavonylflavanonol together with two known flavonoids, 6-methyl-4'-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC50 values of 28.0 and 20.4 µM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.
Keywords: Garcinia nervosa var. pubescens; biflavonoid; platelet-activating factor (PAF) antagonists; platelets Garcinia nervosa var. pubescens; biflavonoid; platelet-activating factor (PAF) antagonists; platelets
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Jalil, J.; Jantan, I.; Ghani, A.A.; Murad, S. Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King. Molecules 2012, 17, 10893-10901.

AMA Style

Jalil J, Jantan I, Ghani AA, Murad S. Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King. Molecules. 2012; 17(9):10893-10901.

Chicago/Turabian Style

Jalil, Juriyati; Jantan, Ibrahim; Ghani, Azura Abdul; Murad, Shahnaz. 2012. "Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King." Molecules 17, no. 9: 10893-10901.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert