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• Jantan, I
• Ghani, A
• Murad, S
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• Jantan, I
• Ghani, A
• Murad, S
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• Jantan, I
• Ghani, A
• Murad, S

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Molecules 2012, 17(9), 10893-10901; doi:10.3390/molecules170910893

Article

Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King

Juriyati Jalil ^1,* , Ibrahim Jantan ¹ , Azura Abdul Ghani ¹  and Shahnaz Murad ²

¹ Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia ² Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia

* Author to whom correspondence should be addressed.

Received: 30 July 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 10 September 2012

(This article belongs to the Section Natural Products)

Download PDF Full-Text [188 KB, uploaded 10 September 2012 15:16 CEST]

Abstract: The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8)-flavonylflavanonol together with two known flavonoids, 6-methyl-4'-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using ³H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC₅₀ values of 28.0 and 20.4 µM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.

Keywords: Garcinia nervosa var. pubescens; biflavonoid; platelet-activating factor (PAF) antagonists; platelets

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