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Molecules 2012, 17(9), 10094-10107; doi:10.3390/molecules170910094
Article

Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against Candida albicans

1
,
2
,
2
 and
2,*
1 Post Graduate Program in Pharmaceutical Sciences, Universidade Estadual de Maringá, Av. Colombo, 5790, Maringá 87020-900, Parana, Brazil 2 Department of Health Sciences, Universidade Estadual de Maringá, Av. Colombo, 5790, Maringá 87020-900, Parana, Brazil
* Author to whom correspondence should be addressed.
Received: 30 April 2012 / Revised: 20 July 2012 / Accepted: 21 July 2012 / Published: 24 August 2012
(This article belongs to the Section Metabolites)
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Abstract

Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 µm and 2.80 µm, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models.
Keywords: microparticles; pomegranate; antifungal activity; Candida albicans microparticles; pomegranate; antifungal activity; Candida albicans
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Endo, E.H.; Ueda-Nakamura, T.; Nakamura, C.V.; Filho, B.P.D. Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against Candida albicans. Molecules 2012, 17, 10094-10107.

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