Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses †
AbstractA novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses.
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Nohara, T.; Imamura, A.; Yamaguchi, M.; Hidari, K.I.P.J.; Suzuki, T.; Komori, T.; Ando, H.; Ishida, H.; Kiso, M. Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses †. Molecules 2012, 17, 9590-9620.
Nohara T, Imamura A, Yamaguchi M, Hidari KIPJ, Suzuki T, Komori T, Ando H, Ishida H, Kiso M. Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses †. Molecules. 2012; 17(8):9590-9620.Chicago/Turabian Style
Nohara, Tomohiro; Imamura, Akihiro; Yamaguchi, Maho; Hidari, Kazuya I. P. J.; Suzuki, Takashi; Komori, Tatsuya; Ando, Hiromune; Ishida, Hideharu; Kiso, Makoto. 2012. "Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses †." Molecules 17, no. 8: 9590-9620.