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Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300071, China
School of Medicine, Nankai University, Tianjin 300071, China
Department of Analytical Chemistry, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 9 July 2012; in revised form: 25 July 2012 / Accepted: 26 July 2012 / Published: 9 August 2012
Abstract: Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
Keywords: Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities
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MDPI and ACS Style
Xu, J.; Jin, D.; Guo, P.; Xie, C.; Fang, L.; Guo, Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules 2012, 17, 9520-9528.
Xu J, Jin D, Guo P, Xie C, Fang L, Guo Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules. 2012; 17(8):9520-9528.
Xu, Jing; Jin, Daqing; Guo, Ping; Xie, Chunfeng; Fang, Lingzhi; Guo, Yuanqiang. 2012. "Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities." Molecules 17, no. 8: 9520-9528.