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Molecules 2012, 17(8), 9520-9528; doi:10.3390/molecules17089520
Article

Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities

1, 2, 3, 1, 1 and 1,4,*
1 State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300071, China 2 School of Medicine, Nankai University, Tianjin 300071, China 3 Department of Analytical Chemistry, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 9 July 2012 / Revised: 25 July 2012 / Accepted: 26 July 2012 / Published: 9 August 2012
(This article belongs to the Section Natural Products)
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Abstract

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
Keywords: Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xu, J.; Jin, D.; Guo, P.; Xie, C.; Fang, L.; Guo, Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules 2012, 17, 9520-9528.

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