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Molecules 2012, 17(8), 9520-9528; doi:10.3390/molecules17089520

Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities

1, 2, 3, 1, 1 and 1,4,*
1 State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300071, China 2 School of Medicine, Nankai University, Tianjin 300071, China 3 Department of Analytical Chemistry, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 9 July 2012 / Revised: 25 July 2012 / Accepted: 26 July 2012 / Published: 9 August 2012
(This article belongs to the Section Natural Products)
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Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
Keywords: Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, J.; Jin, D.; Guo, P.; Xie, C.; Fang, L.; Guo, Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules 2012, 17, 9520-9528.

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