Molecules 2012, 17(8), 9520-9528; doi:10.3390/molecules17089520
Article

Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities

1, 2, 3, 1, 1 and 1,4,* email
Received: 9 July 2012; in revised form: 25 July 2012 / Accepted: 26 July 2012 / Published: 9 August 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
Keywords: Euphorbia prolifera; diterpenoids; myrsinol diterpenes; neuroprotective activities
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MDPI and ACS Style

Xu, J.; Jin, D.; Guo, P.; Xie, C.; Fang, L.; Guo, Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules 2012, 17, 9520-9528.

AMA Style

Xu J, Jin D, Guo P, Xie C, Fang L, Guo Y. Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities. Molecules. 2012; 17(8):9520-9528.

Chicago/Turabian Style

Xu, Jing; Jin, Daqing; Guo, Ping; Xie, Chunfeng; Fang, Lingzhi; Guo, Yuanqiang. 2012. "Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities." Molecules 17, no. 8: 9520-9528.

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