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Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia
Faculty of Mathematics and Natural Sciences, Haluoleo University, Kendari 93232, Sulawesi Tenggara, Indonesia
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia
Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia Kuala Lumpur, Jalan Semarak, Kuala Lumpur 54100, Malaysia
* Author to whom correspondence should be addressed.
Received: 1 June 2012; in revised form: 10 July 2012 / Accepted: 18 July 2012 / Published: 30 July 2012
Abstract: A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC50s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC50s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC50 values between 161 to 830 µM.
Keywords: Dipterocarpaceae; Shorea acuminata; resveratrol oligomer; acuminatol; antioxidant activity; cytotoxicity
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Muhammad, N.; Din, L.B.; Sahidin, I.; Hashim, S.F.; Ibrahim, N.; Zakaria, Z.; Yaacob, W.A. Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata. Molecules 2012, 17, 9043-9055.
Muhammad N, Din LB, Sahidin I, Hashim SF, Ibrahim N, Zakaria Z, Yaacob WA. Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata. Molecules. 2012; 17(8):9043-9055.
Muhammad, Norhayati; Din, Laily B.; Sahidin, Idin; Hashim, Siti Farah; Ibrahim, Nazlina; Zakaria, Zuriati; Yaacob, Wan A. 2012. "Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata." Molecules 17, no. 8: 9043-9055.