Next Article in Journal
Synthesis and Characterization of Cationic Glycidyl-Based Poly(aminoester)-Folic Acid Targeting Conjugates and Study on Gene Delivery
Previous Article in Journal
Synthesis, Antigenicity Against Human Sera and Structure-Activity Relationships of Carbohydrate Moieties from Toxocara larvae and Their Analogues
Molecules 2012, 17(8), 9043-9055; doi:10.3390/molecules17089043
Article

Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata

1
,
1
,
2
,
3
,
3
,
4
 and
1,*
1 School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia 2 Faculty of Mathematics and Natural Sciences, Haluoleo University, Kendari 93232, Sulawesi Tenggara, Indonesia 3 School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia 4 Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia Kuala Lumpur, Jalan Semarak, Kuala Lumpur 54100, Malaysia
* Author to whom correspondence should be addressed.
Received: 1 June 2012 / Revised: 10 July 2012 / Accepted: 18 July 2012 / Published: 30 July 2012
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [296 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC50s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC50s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC50 values between 161 to 830 µM.
Keywords: Dipterocarpaceae; Shorea acuminata; resveratrol oligomer; acuminatol; antioxidant activity; cytotoxicity Dipterocarpaceae; Shorea acuminata; resveratrol oligomer; acuminatol; antioxidant activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Muhammad, N.; Din, L.B.; Sahidin, I.; Hashim, S.F.; Ibrahim, N.; Zakaria, Z.; Yaacob, W.A. Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata. Molecules 2012, 17, 9043-9055.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert