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A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra.30 No.45-03, Bogotá 111321, Colombia
* Author to whom correspondence should be addressed.
Received: 4 May 2012; in revised form: 27 June 2012 / Accepted: 9 July 2012 / Published: 17 July 2012
Abstract: A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, 1H-, 13C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%–51.4% yield.
Keywords: benzimidazole-2-thione; benzimidazole; sulfur chemistry; aminal cage
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Rivera, A.; Maldonado, M.; Ríos-Motta, J. A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives. Molecules 2012, 17, 8578-8586.
Rivera A, Maldonado M, Ríos-Motta J. A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives. Molecules. 2012; 17(7):8578-8586.
Rivera, Augusto; Maldonado, Mauricio; Ríos-Motta, Jaime. 2012. "A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives." Molecules 17, no. 7: 8578-8586.