Molecules 2012, 17(7), 8255-8275; doi:10.3390/molecules17078255
Article

Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats

Hammed H. A. M. Hassan 1,2,* email, Sabah G. El-Banna 3 , Amel F. Elhusseiny 1  and El-Sayed M. E. Mansour 1
1 Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 2-Moharram Beck, Alexandria 21598, Egypt 2 Department of Analytical and Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Canal El Mahmoudia Street, Alexandria 21311, Egypt 3 Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt
* Author to whom correspondence should be addressed.
Received: 23 April 2012; in revised form: 7 June 2012 / Accepted: 12 June 2012 / Published: 10 July 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P450, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl4 on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl4 decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl3) upon the liver through inhibition of the cytochrome P450 system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.
Keywords: aramide nanoparticles; thermal analysis; valine; cytochrome P450 enzymes; TBARS

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Cite This Article

MDPI and ACS Style

Hassan, H.H.A.M.; El-Banna, S.G.; Elhusseiny, A.F.; Mansour, E.-S. Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats. Molecules 2012, 17, 8255-8275.

AMA Style

Hassan HHAM, El-Banna SG, Elhusseiny AF, Mansour E-S. Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats. Molecules. 2012; 17(7):8255-8275.

Chicago/Turabian Style

Hassan, Hammed H. A. M.; El-Banna, Sabah G.; Elhusseiny, Amel F.; Mansour, El-Sayed M. E. 2012. "Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats." Molecules 17, no. 7: 8255-8275.

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