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Molecules 2012, 17(6), 7543-7555; doi:10.3390/molecules17067543
Article

Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst

1, 2, 3, 4, 5 and 1,*
Received: 11 May 2012 / Revised: 8 June 2012 / Accepted: 11 June 2012 / Published: 18 June 2012
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Abstract

Polyethyleneglycol bound sulfonic acid (PEG-OSO3H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.
Keywords: aryl aldehydes; 2-naphthol; PEG-OSO3H; neat reaction; xanthenes; tobacco mosaic virus aryl aldehydes; 2-naphthol; PEG-OSO3H; neat reaction; xanthenes; tobacco mosaic virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reddi Mohan Naidu, K.; Satheesh Krishna, B.; Anil Kumar, M.; Arulselvan, P.; Ibrahim Khalivulla, S.; Lasekan, O. Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst. Molecules 2012, 17, 7543-7555.

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