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Molecules 2012, 17(6), 7543-7555; doi:10.3390/molecules17067543

Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst

1
Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
2
Department of Chemistry, Sri Venkateswara University, Tirupati 517502, India
3
Department of Nanomaterial Chemistry, Dongguk University, Gyeongju 780-714, Korea
4
Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
5
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, No.1, Jalan Menera Gading, 56000 Cheras, Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Received: 11 May 2012 / Revised: 8 June 2012 / Accepted: 11 June 2012 / Published: 18 June 2012
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Abstract

Polyethyleneglycol bound sulfonic acid (PEG-OSO3H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.
Keywords: aryl aldehydes; 2-naphthol; PEG-OSO3H; neat reaction; xanthenes; tobacco mosaic virus aryl aldehydes; 2-naphthol; PEG-OSO3H; neat reaction; xanthenes; tobacco mosaic virus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Reddi Mohan Naidu, K.; Satheesh Krishna, B.; Anil Kumar, M.; Arulselvan, P.; Ibrahim Khalivulla, S.; Lasekan, O. Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst. Molecules 2012, 17, 7543-7555.

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