Molecules 2012, 17(6), 6585-6592; doi:10.3390/molecules17066585
Article

A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

1, 1, 1, 1, 2, 3,4, 5, 3, 6,* email and 1,7,* email
Received: 2 May 2012; in revised form: 25 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new butanolide, 3b-((E)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4–179.9 mM.
Keywords: Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory
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MDPI and ACS Style

Yang, C.-P.; Huang, G.-J.; Huang, H.-C.; Chen, Y.-C.; Chang, C.-I.; Wang, S.-Y.; Chen, I.-S.; Tseng, Y.-H.; Chien, S.-C.; Kuo, Y.-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules 2012, 17, 6585-6592.

AMA Style

Yang C-P, Huang G-J, Huang H-C, Chen Y-C, Chang C-I, Wang S-Y, Chen I-S, Tseng Y-H, Chien S-C, Kuo Y-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules. 2012; 17(6):6585-6592.

Chicago/Turabian Style

Yang, Chung-Ping; Huang, Guan-Jhong; Huang, Hui-Chi; Chen, Yu-Chang; Chang, Chi-I; Wang, Sheng-Yang; Chen, Ih-Sheng; Tseng, Yen-Hsueh; Chien, Shih-Chang; Kuo, Yueh-Hsiung. 2012. "A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity." Molecules 17, no. 6: 6585-6592.

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