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A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 2 May 2012; in revised form: 25 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012
Abstract: A new butanolide, 3b-((E)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4–179.9 mM.
Keywords: Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory
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Cite This Article
MDPI and ACS Style
Yang, C.-P.; Huang, G.-J.; Huang, H.-C.; Chen, Y.-C.; Chang, C.-I.; Wang, S.-Y.; Chen, I.-S.; Tseng, Y.-H.; Chien, S.-C.; Kuo, Y.-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules 2012, 17, 6585-6592.
Yang C-P, Huang G-J, Huang H-C, Chen Y-C, Chang C-I, Wang S-Y, Chen I-S, Tseng Y-H, Chien S-C, Kuo Y-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules. 2012; 17(6):6585-6592.
Yang, Chung-Ping; Huang, Guan-Jhong; Huang, Hui-Chi; Chen, Yu-Chang; Chang, Chi-I; Wang, Sheng-Yang; Chen, Ih-Sheng; Tseng, Yen-Hsueh; Chien, Shih-Chang; Kuo, Yueh-Hsiung. 2012. "A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity." Molecules 17, no. 6: 6585-6592.