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Molecules 2012, 17(6), 6585-6592; doi:10.3390/molecules17066585

A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

1
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
3
Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
4
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan
7
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 2 May 2012 / Revised: 25 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012
(This article belongs to the Section Natural Products)
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Abstract

A new butanolide, 3b-((E)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4–179.9 mM.
Keywords: Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, C.-P.; Huang, G.-J.; Huang, H.-C.; Chen, Y.-C.; Chang, C.-I.; Wang, S.-Y.; Chen, I.-S.; Tseng, Y.-H.; Chien, S.-C.; Kuo, Y.-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules 2012, 17, 6585-6592.

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