Molecules 2012, 17(6), 6585-6592; doi:10.3390/molecules17066585
Article

A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

1 School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan 2 Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan 3 Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan 4 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan 7 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 2 May 2012; in revised form: 25 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012
(This article belongs to the Section Natural Products)
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Abstract: A new butanolide, 3b-((E)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4–179.9 mM.
Keywords: Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory

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MDPI and ACS Style

Yang, C.-P.; Huang, G.-J.; Huang, H.-C.; Chen, Y.-C.; Chang, C.-I.; Wang, S.-Y.; Chen, I.-S.; Tseng, Y.-H.; Chien, S.-C.; Kuo, Y.-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules 2012, 17, 6585-6592.

AMA Style

Yang C-P, Huang G-J, Huang H-C, Chen Y-C, Chang C-I, Wang S-Y, Chen I-S, Tseng Y-H, Chien S-C, Kuo Y-H. A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity. Molecules. 2012; 17(6):6585-6592.

Chicago/Turabian Style

Yang, Chung-Ping; Huang, Guan-Jhong; Huang, Hui-Chi; Chen, Yu-Chang; Chang, Chi-I; Wang, Sheng-Yang; Chen, Ih-Sheng; Tseng, Yen-Hsueh; Chien, Shih-Chang; Kuo, Yueh-Hsiung. 2012. "A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity." Molecules 17, no. 6: 6585-6592.

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