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Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid
Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai 318000, Zhejiang, China
* Author to whom correspondence should be addressed.
Received: 11 May 2012; in revised form: 22 May 2012 / Accepted: 23 May 2012 / Published: 30 May 2012
Abstract: We investigated the effects of Fufang Kushen Injection Liquid (FFKSIL) on gastric immunity and oxidant-antioxidant status during N-methyl-N′-nitro-N-nitroso-guanidine (MNNG)-induced gastric carcinogenesis. The extent of lipid peroxidation and the levels of reduced glutathione (GSH) and activities of the GSH-dependent enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were used to monitor the peroxidative balance. Enhanced lipid peroxidation in the gastric cancer animals was accompanied by significant decreases in the activities of GSH, GPx, GST and GR. Administration of FFKSIL significantly enhanced serum IgA, IgG, IgM, IL-2, IL-4 and IL-10 levels, decreased serum IL-6 and TNF-α levels, lowered the levels of lipid peroxides and enhanced GSH levels and activities of GSH-dependent enzymes. Our results suggest that FFKSIL blocks experimental gastric carcinogenesis by protecting against carcinogen-induced oxidative damage and improving immunity activity.
Keywords: FFKSIL; GSH-Px; antioxidant; immunity; Il-2; IgA; TNF-α
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MDPI and ACS Style
Zhou, S.-K.; Zhang, R.-L.; Xu, Y.-F.; Bi, T.-N. Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid. Molecules 2012, 17, 6481-6490.
Zhou S-K, Zhang R-L, Xu Y-F, Bi T-N. Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid. Molecules. 2012; 17(6):6481-6490.
Zhou, Shen-Kang; Zhang, Rui-Li; Xu, Yun-Feng; Bi, Tie-Nan. 2012. "Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid." Molecules 17, no. 6: 6481-6490.