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• Marek, J
• Buchta, V
• Soukup, O
• Stodulka, P
• Cabal, J
• Ghosh, K
• Musilek, K
• Kuca, K
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• Marek, J
• Buchta, V
• Soukup, O
• Stodulka, P
• Cabal, J
• Ghosh, K
• Musilek, K
• Kuca, K
• [+] on PubMed
• Marek, J
• Buchta, V
• Soukup, O
• Stodulka, P
• Cabal, J
• Ghosh, K
• Musilek, K
• Kuca, K

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Molecules 2012, 17(6), 6386-6394; doi:10.3390/molecules17066386

Article

Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain

Jan Marek ^1,2 , Vladimir Buchta ³ , Ondrej Soukup ^4,5 , Petr Stodulka ⁶ , Jiri Cabal ¹ , Kallol K. Ghosh ⁷ , Kamil Musilek ⁸  and Kamil Kuca ^5,6,*

¹ Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic ² Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic ³ Department of Clinical Microbiology, University Hospital, Hradec Kralove, 50005, Czech Republic ⁴ Department of Public Health, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic ⁵ Centre for Biomedical Research, University Hospital, Hradec Kralove, 50005, Czech Republic ⁶ Centre of Advanced Study, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic ⁷ School of Studies in Chemistry, Pt. Ravishankar Shukla University Raipur, Raipur, 492010, India ⁸ Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, Hradec Kralove, 50003, Czech Republic

* Author to whom correspondence should be addressed.

Received: 11 May 2012; in revised form: 16 May 2012 / Accepted: 17 May 2012 / Published: 25 May 2012

Download PDF Full-Text [180 KB, uploaded 25 May 2012 15:30 CEST]

Abstract: Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C₈ to C₂₀) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. In vitro testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and Candida species.

Keywords: quinolinium salts; synthesis; HPLC; surfactants; detergents; disinfectants; in vitro antimicrobial activity

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