Molecules 2012, 17(6), 6386-6394; doi:10.3390/molecules17066386
Article

Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain

1 Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic 2 Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic 3 Department of Clinical Microbiology, University Hospital, Hradec Kralove, 50005, Czech Republic 4 Department of Public Health, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic 5 Centre for Biomedical Research, University Hospital, Hradec Kralove, 50005, Czech Republic 6 Centre of Advanced Study, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic 7 School of Studies in Chemistry, Pt. Ravishankar Shukla University Raipur, Raipur, 492010, India 8 Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, Hradec Kralove, 50003, Czech Republic
* Author to whom correspondence should be addressed.
Received: 11 May 2012; in revised form: 16 May 2012 / Accepted: 17 May 2012 / Published: 25 May 2012
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Abstract: Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C8 to C20) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. In vitro testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and Candida species.
Keywords: quinolinium salts; synthesis; HPLC; surfactants; detergents; disinfectants; in vitro antimicrobial activity

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MDPI and ACS Style

Marek, J.; Buchta, V.; Soukup, O.; Stodulka, P.; Cabal, J.; Ghosh, K.K.; Musilek, K.; Kuca, K. Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain. Molecules 2012, 17, 6386-6394.

AMA Style

Marek J, Buchta V, Soukup O, Stodulka P, Cabal J, Ghosh KK, Musilek K, Kuca K. Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain. Molecules. 2012; 17(6):6386-6394.

Chicago/Turabian Style

Marek, Jan; Buchta, Vladimir; Soukup, Ondrej; Stodulka, Petr; Cabal, Jiri; Ghosh, Kallol K.; Musilek, Kamil; Kuca, Kamil. 2012. "Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain." Molecules 17, no. 6: 6386-6394.

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