Next Article in Journal
Biological Activities of a-Pinene and β-Pinene Enantiomers
Previous Article in Journal
Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression
Molecules 2012, 17(6), 6290-6304; doi:10.3390/molecules17066290
Review

Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells

1,*  and 2
Received: 28 March 2012; in revised form: 28 April 2012 / Accepted: 9 May 2012 / Published: 25 May 2012
(This article belongs to the Section Metabolites)
Download PDF [592 KB, uploaded 18 June 2014]
Abstract: Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by scientists for their health-promoting potential. One such a compound which has been comprehensively used is eugenol (4-allyl-2-methoxyphenol), which is the active component of Syzigium aromaticum (cloves). Aromatic plants like nutmeg, basil, cinnamon and bay leaves also contain eugenol. Eugenol has a wide range of applications like perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic. Increasing volumes of literature showed eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells has been well documented. This review article will highlight the antiproliferative activity and molecular mechanism of the eugenol induced apoptosis against the cancer cells and animal models.
Keywords: eugenol; antiproliferative; cancer; chemoprevention eugenol; antiproliferative; cancer; chemoprevention
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Jaganathan, S.K.; Supriyanto, E. Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells. Molecules 2012, 17, 6290-6304.

AMA Style

Jaganathan SK, Supriyanto E. Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells. Molecules. 2012; 17(6):6290-6304.

Chicago/Turabian Style

Jaganathan, Saravana Kumar; Supriyanto, Eko. 2012. "Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells." Molecules 17, no. 6: 6290-6304.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert