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Molecules 2012, 17(6), 6269-6276; doi:10.3390/molecules17066269

α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves

Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China
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Received: 19 April 2012 / Revised: 16 May 2012 / Accepted: 21 May 2012 / Published: 25 May 2012
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Abstract

A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant α-glucosidase inhibition activity.
Keywords: Acanthopanax senticosus Harms; triterpene glycoside; alkaloid; α-glucosidase inhibition activity Acanthopanax senticosus Harms; triterpene glycoside; alkaloid; α-glucosidase inhibition activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, Z.-B.; Jiang, H.; Xia, Y.-G.; Yang, B.-Y.; Kuang, H.-X. α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves. Molecules 2012, 17, 6269-6276.

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