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α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China
* Author to whom correspondence should be addressed.
Received: 19 April 2012; in revised form: 16 May 2012 / Accepted: 21 May 2012 / Published: 25 May 2012
Abstract: A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant α-glucosidase inhibition activity.
Keywords: Acanthopanax senticosus Harms; triterpene glycoside; alkaloid; α-glucosidase inhibition activity
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Wang, Z.-B.; Jiang, H.; Xia, Y.-G.; Yang, B.-Y.; Kuang, H.-X. α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves. Molecules 2012, 17, 6269-6276.
Wang Z-B, Jiang H, Xia Y-G, Yang B-Y, Kuang H-X. α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves. Molecules. 2012; 17(6):6269-6276.
Wang, Zhi-Bin; Jiang, Hai; Xia, Yong-Gang; Yang, Bing-You; Kuang, Hai-Xue. 2012. "α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves." Molecules 17, no. 6: 6269-6276.