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Fluorescent Nanoprobes Dedicated to in Vivo Imaging: From Preclinical Validations to Clinical Translation
Département microTechnologies pour la Biologie et la Santé CEA-LETI, Minatec, 17 rue des Martyrs, 38045 Grenoble cedex, France
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Received: 5 April 2012; in revised form: 6 May 2012 / Accepted: 7 May 2012 / Published: 10 May 2012
Abstract: With the fast development, in the last ten years, of a large choice of set-ups dedicated to routine in vivo measurements in rodents, fluorescence imaging techniques are becoming essential tools in preclinical studies. Human clinical uses for diagnostic and image-guided surgery are also emerging. In comparison to low-molecular weight organic dyes, the use of fluorescent nanoprobes can improve both the signal sensitivity (better in vivo optical properties) and the fluorescence biodistribution (passive “nano” uptake in tumours for instance). A wide range of fluorescent nanoprobes have been designed and tested in preclinical studies for the last few years. They will be reviewed and discussed considering the obstacles that need to be overcome for their potential everyday use in clinics. The conjugation of fluorescence imaging with the benefits of nanotechnology should open the way to new medical applications in the near future.
Keywords: fluorescence imaging; nanoprobes; in vivo imaging; nanoparticles; organic dyes; quantum dots; contrast agents, biodistribution; lymph node mapping
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Mérian, J.; Gravier, J.; Navarro, F.; Texier, I. Fluorescent Nanoprobes Dedicated to in Vivo Imaging: From Preclinical Validations to Clinical Translation. Molecules 2012, 17, 5564-5591.
Mérian J, Gravier J, Navarro F, Texier I. Fluorescent Nanoprobes Dedicated to in Vivo Imaging: From Preclinical Validations to Clinical Translation. Molecules. 2012; 17(5):5564-5591.
Mérian, Juliette; Gravier, Julien; Navarro, Fabrice; Texier, Isabelle. 2012. "Fluorescent Nanoprobes Dedicated to in Vivo Imaging: From Preclinical Validations to Clinical Translation." Molecules 17, no. 5: 5564-5591.