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Molecules 2012, 17(5), 5544-5549; doi:10.3390/molecules17055544

Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China
2
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Peking Union Medical College, Beijing 100193, China
3
Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Received: 9 April 2012 / Revised: 26 April 2012 / Accepted: 27 April 2012 / Published: 9 May 2012
(This article belongs to the Section Natural Products)
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Abstract

Two new aryltetralin-type lignans, dolomiaeasin A (1) and dolomiaeasin B (2), were isolated from the roots of Dolomiaea souliei. Their structures were elucidated by means of various spectroscopic analyses. The cytotoxicities of 1 and 2 were tested by the MTT method, and both compounds showed no significant cytotoxic activities against the A549 and A2780 human cancer cell lines. This is the first time that aryltetralin-type lignans were isolated from the genus Dolomiaea.
Keywords: Compositae; Dolomiaea souliei; aryltetralin; cytotoxicity Compositae; Dolomiaea souliei; aryltetralin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wei, H.; He, C.; Peng, Y.; Zhang, S.; Chen, X.; Xiao, P. Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei. Molecules 2012, 17, 5544-5549.

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