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Molecules 2012, 17(5), 5544-5549; doi:10.3390/molecules17055544
Article

Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei

1,2, 1,2, 1,2, 3, 3 and 1,2,*
1 Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China 2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Peking Union Medical College, Beijing 100193, China 3 Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China
* Author to whom correspondence should be addressed.
Received: 9 April 2012 / Revised: 26 April 2012 / Accepted: 27 April 2012 / Published: 9 May 2012
(This article belongs to the Section Metabolites)
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Abstract

Two new aryltetralin-type lignans, dolomiaeasin A (1) and dolomiaeasin B (2), were isolated from the roots of Dolomiaea souliei. Their structures were elucidated by means of various spectroscopic analyses. The cytotoxicities of 1 and 2 were tested by the MTT method, and both compounds showed no significant cytotoxic activities against the A549 and A2780 human cancer cell lines. This is the first time that aryltetralin-type lignans were isolated from the genus Dolomiaea.
Keywords: Compositae; Dolomiaea souliei; aryltetralin; cytotoxicity Compositae; Dolomiaea souliei; aryltetralin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wei, H.; He, C.; Peng, Y.; Zhang, S.; Chen, X.; Xiao, P. Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei. Molecules 2012, 17, 5544-5549.

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