Molecules 2012, 17(5), 5081-5094; doi:10.3390/molecules17055081
Article

A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones

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Received: 7 March 2012; in revised form: 19 April 2012 / Accepted: 20 April 2012 / Published: 3 May 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation.
Keywords: one-pot procedure; Morita-Baylis-Hillman adducts; quinolines; reductive cyclization; Fe/AcOH
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MDPI and ACS Style

Ramesh, C.; Lei, P.-M.; Kavala, V.; Kuo, C.-W.; Yao, C.-F. A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones. Molecules 2012, 17, 5081-5094.

AMA Style

Ramesh C, Lei P-M, Kavala V, Kuo C-W, Yao C-F. A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones. Molecules. 2012; 17(5):5081-5094.

Chicago/Turabian Style

Ramesh, Chintakunta; Lei, Po-Min; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa. 2012. "A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones." Molecules 17, no. 5: 5081-5094.

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