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Molecules 2012, 17(5), 4936-4949; doi:10.3390/molecules17054936
Article

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

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Received: 12 March 2012 / Revised: 18 April 2012 / Accepted: 20 April 2012 / Published: 30 April 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
Keywords: pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ilieva, E.D.; Petkova, N.I.; Nikolova, R.D. A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones. Molecules 2012, 17, 4936-4949.

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