Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(5), 4936-4949; doi:10.3390/molecules17054936
Article

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

,  and *
Received: 12 March 2012; in revised form: 18 April 2012 / Accepted: 20 April 2012 / Published: 30 April 2012
(This article belongs to the Section Organic Synthesis)
Download PDF [259 KB, uploaded 18 June 2014]
Abstract: A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
Keywords: pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Ilieva, E.D.; Petkova, N.I.; Nikolova, R.D. A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones. Molecules 2012, 17, 4936-4949.

AMA Style

Ilieva ED, Petkova NI, Nikolova RD. A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones. Molecules. 2012; 17(5):4936-4949.

Chicago/Turabian Style

Ilieva, Eleonora D.; Petkova, Nevena I.; Nikolova, Rositca D. 2012. "A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones." Molecules 17, no. 5: 4936-4949.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert